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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

drosha  -  CG8730 gene product from transcript CG8730-RA

Drosophila melanogaster

Synonyms: CG8730, DROSHA, Dmel\CG8730, Drosha
 
 
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High impact information on drosha

  • The results reveal that transcripts differentially expressed in Drosha-depleted cells have highly correlated expression in the AGO1 knockdown and are significantly enriched in predicted and validated miRNA targets [1].
  • The Drosha-Pasha/DGCR8 complex in the nucleus cleaves pri-miRNAs to release hairpin-shaped precursor miRNAs (pre-miRNAs) [2].
 

Biological context of drosha

References

  1. Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Rehwinkel, J., Natalin, P., Stark, A., Brennecke, J., Cohen, S.M., Izaurralde, E. Mol. Cell. Biol. (2006) [Pubmed]
  2. Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells. Saito, K., Ishizuka, A., Siomi, H., Siomi, M.C. PLoS Biol. (2005) [Pubmed]
  3. Processing of primary microRNAs by the Microprocessor complex. Denli, A.M., Tops, B.B., Plasterk, R.H., Ketting, R.F., Hannon, G.J. Nature (2004) [Pubmed]
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