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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

drsh-1  -  Protein DRSH-1

Caenorhabditis elegans

 
 
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High impact information on drsh-1

  • In plants, animals, and fungi, members of the Dicer family of RNase III-related enzymes process double-stranded RNA (dsRNA) to initiate small-RNA-mediated gene-silencing mechanisms [1].
  • In RNA interference, the RNase-III enzyme Dicer processes exogenous double-stranded RNA into small interfering RNAs (siRNAs). siRNAs guide RNA-induced silencing complexes to cleave homologous transcripts, enabling gene-specific knock-down [2].
  • A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans [3].

References

  1. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine, T.F., Wohlschlegel, J.A., Kennedy, S., Bei, Y., Conte, D., Pang, K., Brownell, D.R., Harding, S., Mitani, S., Ruvkun, G., Yates, J.R., Mello, C.C. Cell (2006) [Pubmed]
  2. DICER-LIKE 4 is required for RNA interference and produces the 21-nucleotide small interfering RNA component of the plant cell-to-cell silencing signal. Dunoyer, P., Himber, C., Voinnet, O. Nat. Genet. (2005) [Pubmed]
  3. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Knight, S.W., Bass, B.L. Science (2001) [Pubmed]
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