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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mtt  -  mangetout

Drosophila melanogaster

Synonyms: CG18447, CG30361, CG8692, DmGluBR, DmGluRB, ...
 
 
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High impact information on mXr

  • Similar to Drosophila DmXR, the residues of mGluRs involved in the binding of the alpha-carboxylic and alpha-amino groups of glutamate were well conserved in DdmGluPR, but the residues interacting with the gamma-carboxylic group of glutamate were not [1].
  • Here we report the identification of a new receptor homologous to mGluRs found in Anopheles gambiae, Apis mellifera, and Drosophila melanogaster genomes and called AmXR, HBmXR, and DmXR, respectively (the mXRs group) [2].
 

Associations of mXr with chemical compounds

  • The Drosophila cDNA encoding DmXR was isolated and found to be insensitive to glutamate or any other standard amino acid [2].

References

  1. A Metabotropic Glutamate Receptor Family Gene in Dictyostelium discoideum. Taniura, H., Sanada, N., Kuramoto, N., Yoneda, Y. J. Biol. Chem. (2006) [Pubmed]
  2. Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects. Mitri, C., Parmentier, M.L., Pin, J.P., Bockaert, J., Grau, Y. J. Biol. Chem. (2004) [Pubmed]
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