The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GRM8  -  glutamate receptor, metabotropic 8

Homo sapiens

Synonyms: GLUR8, GPRC1H, MGLUR8, Metabotropic glutamate receptor 8, mGlu8, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GRM8

  • Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions [1].
  • The Tyr433Phe polymorphism of mGluR7 and a novel polymorphism in the mGluR8 gene located 29 bp after the termination codon (2756C/T) were investigated in case control association studies performed on DNA from more than 100 patients with idiopathic generalised epilepsy (IGE) [2].

Psychiatry related information on GRM8


High impact information on GRM8

  • Osteoclasts express mGluR8, a class III metabotropic glutamate receptor [4].
  • Metabotropic glutamate receptor (mGluR) subtypes (mGluR1 to mGluR8) act as important pre- and postsynaptic regulators of neurotransmission in the CNS [5].
  • Significantly, these compounds did not affect responses elicited by the homologous metabotropic glutamate receptors, mGluR1a, mGluR2, or mGluR8 [6].
  • In contrast, in active lesions, mGluR8 immunoreactivity (IR) was detected in cells of the microglia/macrophage lineage [1].
  • In chronic active lesions, however, a population of reactive astrocytes localized in the rim of the lesions expressed both mGluR4 and mGluR8 [1].

Biological context of GRM8


Anatomical context of GRM8


Associations of GRM8 with chemical compounds


Other interactions of GRM8

  • However, modest (approximately 20% of mGlu2/3) specific [3H]-LY341495 (1 nM) binding was observed in human mGlu8 expressing cells [15].
  • 4. LY341495 exhibited low-nanomolar potency antagonist activity against (S)-AP4 and ACPT-I suggesting that these agonists are activating predominantly mGlu8 and that mGlu4 receptors do not play a role in modulating synaptic transmission in the pathways stimulated in the experiments described here [16].
  • No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study [2].

Analytical, diagnostic and therapeutic context of GRM8


  1. Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions. Geurts, J.J., Wolswijk, G., Bö, L., Redeker, S., Ramkema, M., Troost, D., Aronica, E. J. Neuroimmunol. (2005) [Pubmed]
  2. No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study. Goodwin, H., Curran, N., Chioza, B., Blower, J., Nashef, L., Asherson, P., Makoff, A.J. Epilepsy Res. (2000) [Pubmed]
  3. Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder. Kobayashi, Y., Akiyoshi, J., Kanehisa, M., Ichioka, S., Tanaka, Y., Tsuru, J., Hanada, H., Kodama, K., Isogawa, K., Tsutsumi, T. Psychiatr. Genet. (2007) [Pubmed]
  4. Secretion of L-glutamate from osteoclasts through transcytosis. Morimoto, R., Uehara, S., Yatsushiro, S., Juge, N., Hua, Z., Senoh, S., Echigo, N., Hayashi, M., Mizoguchi, T., Ninomiya, T., Udagawa, N., Omote, H., Yamamoto, A., Edwards, R.H., Moriyama, Y. EMBO J. (2006) [Pubmed]
  5. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Mitsukawa, K., Yamamoto, R., Ofner, S., Nozulak, J., Pescott, O., Lukic, S., Stoehr, N., Mombereau, C., Kuhn, R., McAllister, K.H., van der Putten, H., Cryan, J.F., Flor, P.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Nemeth, E.F., Steffey, M.E., Hammerland, L.G., Hung, B.C., Van Wagenen, B.C., DelMar, E.G., Balandrin, M.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. Scherer, S.W., Duvoisin, R.M., Kuhn, R., Heng, H.H., Belloni, E., Tsui, L.C. Genomics (1996) [Pubmed]
  8. The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1. Scherer, S.W., Soder, S., Duvoisin, R.M., Huizenga, J.J., Tsui, L.C. Genomics (1997) [Pubmed]
  9. Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia. Takaki, H., Kikuta, R., Shibata, H., Ninomiya, H., Tashiro, N., Fukumaki, Y. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
  10. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Kingston, A.E., Ornstein, P.L., Wright, R.A., Johnson, B.G., Mayne, N.G., Burnett, J.P., Belagaje, R., Wu, S., Schoepp, D.D. Neuropharmacology (1998) [Pubmed]
  11. Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia. Bolonna, A.A., Kerwin, R.W., Munro, J., Arranz, M.J., Makoff, A.J. Schizophr. Res. (2001) [Pubmed]
  12. (2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors. Wheeler, W.J., Clodfelter, D.K., Collado, I., Kulanthaivel, P., Pedregal, C., Stoddard, E.A., Wright, R.A., Schoepp, D.D. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  13. Localization and function of metabotropic glutamate receptor 8 in the enteric nervous system. Tong, Q., Kirchgessner, A.L. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  14. Molecular determinants of high affinity binding to group III metabotropic glutamate receptors. Rosemond, E., Peltekova, V., Naples, M., Thøgersen, H., Hampson, D.R. J. Biol. Chem. (2002) [Pubmed]
  15. [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Johnson, B.G., Wright, R.A., Arnold, M.B., Wheeler, W.J., Ornstein, P.L., Schoepp, D.D. Neuropharmacology (1999) [Pubmed]
  16. Actions of LY341495 on metabotropic glutamate receptor-mediated responses in the neonatal rat spinal cord. Howson, P.A., Jane, D.E. Br. J. Pharmacol. (2003) [Pubmed]
  17. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Malherbe, P., Kratzeisen, C., Lundstrom, K., Richards, J.G., Faull, R.L., Mutel, V. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  18. Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors. Peltekova, V., Han, G., Soleymanlou, N., Hampson, D.R. Brain Res. Mol. Brain Res. (2000) [Pubmed]
WikiGenes - Universities