Gene Review:
Rab40c - Rab40c, member RAS oncogene family
Rattus norvegicus
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High impact information on Rab40c
- Vesicle transport in oligodendrocytes: probable role of Rab40c protein [1].
- The DNA sequence of Rab40c shows an 843-base pair open reading frame [1].
- Binding studies indicate that Rab40c binds guanosine 5'-0-(3-thiotriphosphate) (GTP gamma S) with a K(d) of 21 microM and has a higher affinity for guanosine triphosphate (GTP) than for guanosine diphosphate (GDP) [1].
- We cloned a novel Rab protein from an oligodendrocyte cDNA library, designating it Rab40c because of its homology with Rab40a and Rab40b [1].
- The importance of this recycling in myelin formation is suggested by the increase in both Rab40c mRNA and Rab40c protein as oligodendrocytes differentiate [1].
Biological context of Rab40c
- Rab40c presents a number of distinct structural features including a carboxyl terminal extension and amino acid substitutions in the consensus sequence of the GTP-binding motifs [1].
References
- Vesicle transport in oligodendrocytes: probable role of Rab40c protein. Rodriguez-Gabin, A.G., Almazan, G., Larocca, J.N. J. Neurosci. Res. (2004) [Pubmed]
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