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Gene Review

wnt2ba  -  wingless-type MMTV integration site family...

Danio rerio

Synonyms: SO:0000704
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High impact information on wnt2b

  • We find that RA activity, but not Fgf signaling, is necessary for wnt2b expression [1].
  • Fgf8, which is expressed in the intermediate mesoderm, is thought to initiate forelimb formation by activating wnt2b, which then induces the expression of tbx5 in the adjacent lateral plate mesoderm [2].
  • Zebrafish wnt2b acquired N-terminal cytoplasmic region to evolve into type II transmembrane protein, and then mammalian Wnt2b orthologs acquired integrin-targeting RGD motif within the extracellular WNT domain [3].


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