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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

wnt2ba  -  wingless-type MMTV integration site family...

Danio rerio

Synonyms: SO:0000704
 
 
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High impact information on wnt2b

  • We find that RA activity, but not Fgf signaling, is necessary for wnt2b expression [1].
  • Fgf8, which is expressed in the intermediate mesoderm, is thought to initiate forelimb formation by activating wnt2b, which then induces the expression of tbx5 in the adjacent lateral plate mesoderm [2].
  • Zebrafish wnt2b acquired N-terminal cytoplasmic region to evolve into type II transmembrane protein, and then mammalian Wnt2b orthologs acquired integrin-targeting RGD motif within the extracellular WNT domain [3].

References

  1. Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction. Mercader, N., Fischer, S., Neumann, C.J. Development (2006) [Pubmed]
  2. The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation. Fischer, S., Draper, B.W., Neumann, C.J. Development (2003) [Pubmed]
  3. Molecular evolution of Wnt2b orthologs. Katoh, M. Int. J. Oncol. (2005) [Pubmed]
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