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Gene Review

Wnt2b  -  wingless-type MMTV integration site family...

Mus musculus

Synonyms: Protein Wnt-13, Protein Wnt-2b, Wnt13
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High impact information on Wnt2b

  • In addition, our results suggest that Gbx2 normally promotes dorsal fates such as the endolymphatic duct and semicircular canals by positively regulating genes such as Wnt2b and Dlx5 [1].
  • The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10 [2].
  • By contrast, three others, Wnt3a, 5a and a novel mouse Wnt gene, Wnt2b, are expressed only at the medial edge of the telencephalon, defining the hem of the cerebral cortex [3].
  • By complementing these results with in situ hybridization, we revealed new expression domains for Wnt2b and Sfrp1, respectively, in the future primitive streak at the posterior side and in the anterior visceral endoderm before the initiation of gastrulation [4].
  • Moreover, we show that Wnt-13 is expressed in the pigment epithelium overlying the distal part of the eyecup and the ciliary margin and that Mfz-4, -6, and -7 are expressed in different regions within the ciliary margin [5].

Biological context of Wnt2b


Anatomical context of Wnt2b

  • Furthermore, our results indicate that Tbx5 and Wnt2b function together to initiate and specify forelimb outgrowth and identity [2].
  • Wnt13 is expressed in the embryonic mesoderm during gastrulation [9].

Associations of Wnt2b with chemical compounds

  • Twenty-four Cys residues were conserved among vertebrate Wnt2b and Wnt2 orthologs [8].

Other interactions of Wnt2b


  1. Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. Lin, Z., Cantos, R., Patente, M., Wu, D.K. Development (2005) [Pubmed]
  2. The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Ng, J.K., Kawakami, Y., Büscher, D., Raya, A., Itoh, T., Koth, C.M., Rodríguez Esteban, C., Rodríguez-León, J., Garrity, D.M., Fishman, M.C., Izpisúa Belmonte, J.C. Development (2002) [Pubmed]
  3. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Grove, E.A., Tole, S., Limon, J., Yip, L., Ragsdale, C.W. Development (1998) [Pubmed]
  4. Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. Kemp, C., Willems, E., Abdo, S., Lambiv, L., Leyns, L. Dev. Dyn. (2005) [Pubmed]
  5. Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina. Liu, H., Mohamed, O., Dufort, D., Wallace, V.A. Dev. Dyn. (2003) [Pubmed]
  6. Molecular mechanisms underlying inner ear patterning defects in kreisler mutants. Choo, D., Ward, J., Reece, A., Dou, H., Lin, Z., Greinwald, J. Dev. Biol. (2006) [Pubmed]
  7. Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation. Lako, M., Lindsay, S., Lincoln, J., Cairns, P.M., Armstrong, L., Hole, N. Mech. Dev. (2001) [Pubmed]
  8. Molecular evolution of Wnt2b orthologs. Katoh, M. Int. J. Oncol. (2005) [Pubmed]
  9. Structure and expression of Wnt13, a novel mouse Wnt2 related gene. Zakin, L.D., Mazan, S., Maury, M., Martin, N., Guénet, J.L., Brûlet, P. Mech. Dev. (1998) [Pubmed]
  10. Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Heller, R.S., Dichmann, D.S., Jensen, J., Miller, C., Wong, G., Madsen, O.D., Serup, P. Dev. Dyn. (2002) [Pubmed]
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