High impact information on Wnt2b

• In addition, our results suggest that Gbx2 normally promotes dorsal fates such as the endolymphatic duct and semicircular canals by positively regulating genes such as Wnt2b and Dlx5 [1].
• The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10 [2].
• By contrast, three others, Wnt3a, 5a and a novel mouse Wnt gene, Wnt2b, are expressed only at the medial edge of the telencephalon, defining the hem of the cerebral cortex [3].
• By complementing these results with in situ hybridization, we revealed new expression domains for Wnt2b and Sfrp1, respectively, in the future primitive streak at the posterior side and in the anterior visceral endoderm before the initiation of gastrulation [4].
• Moreover, we show that Wnt-13 is expressed in the pigment epithelium overlying the distal part of the eyecup and the ciliary margin and that Mfz-4, -6, and -7 are expressed in different regions within the ciliary margin [5].

Biological context of Wnt2b

• Our results indicate that the loss of dorsal otic structures such as the endolymphatic duct and sac is attributable to the downregulation of Gbx2, Dlx5 and Wnt2b in the dorsal region of the otocyst [6].
• Using reverse-transcriptase polymerase chain reaction analysis we identified several candidate Wnt genes whose expression pattern was consistent with a role in generation, maintenance and/or differentiation of early haematopoietic progenitor cells including three genes previously shown to have a role in haematopoiesis (Wnt5a, Wnt2b and Wnt10b) [7].
• Molecular evolution of Wnt2b orthologs [8].
• The rat Wnt2b gene, consisting of five exons, was located within AC106372.5 genome sequence [8].
• GC content of rat Wnt2b promoter was 71.8% [8].

Anatomical context of Wnt2b

• Furthermore, our results indicate that Tbx5 and Wnt2b function together to initiate and specify forelimb outgrowth and identity [2].
• Wnt13 is expressed in the embryonic mesoderm during gastrulation [9].

Associations of Wnt2b with chemical compounds

• Twenty-four Cys residues were conserved among vertebrate Wnt2b and Wnt2 orthologs [8].

Other interactions of Wnt2b

• Other members expressed are Wnt2b, Wnt5b, and Wnt11 [10].
• Structure and expression of Wnt13, a novel mouse Wnt2 related gene [9].

References