Disease relevance of CYCSP38

• In the HSIL category, the sensitivity, which was calculated using Grade 2 or greater cervical intraepithelial neoplasia as the endpoint, was 78% (50 of 66 specimens) for p16(INK4a) and 91% (60 of 66 specimens) for HC2 [1].
• Expression and phylogenetic analyses of human endogenous retrovirus HC2 belonging to the HERV-T family in human tissues and cancer cells [2].

High impact information on CYCSP38

• Genotyping of 20 HC2-negative/AMP-positive cases using alternative technologies revealed target HR genotypes in 63.1% of cases and low-risk types in 15.7% of cases, while 21% of cases were negative [3].
• Expression analyses suggest that the pol gene of HERV-HC2 family is more actively transcribed in human cancer cells than in normal tissues, suggesting a functional role during carcinogenesis [2].
• Phylogenetic analysis of the HERV-HC2 pol family revealed three groups (I, II, and III) generated through evolutionary divergence during primate evolution, indicating that they were integrated into primate genomes approximately 56 million years (MY) ago and have evolved at a rate of 0.2% nucleotide differences per MY [2].

Analytical, diagnostic and therapeutic context of CYCSP38

• Specificity was similar for ASCUS+ cytology (69.1%, 95% CI, 64.6-73.3%) and PCR for carcinogenic HPV (67.1%, P = 0.5), yet was lower for HC2 (63.8%, P = 0.048) and combination testing (62.9%, P = 0.02) [4].

References