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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

stat5a  -  signal transducer and activator of...

Danio rerio

Synonyms: SO:0000704, Stat5, stat5, stat5.1, stat5b
 
 
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High impact information on stat5.1

  • RESULTS: Two of these stat5.1 mutants (N646H and H298R/N714F) showed increased tyrosine phosphorylation and transactivation activity compared to the wild-type protein [1].
  • 2. The stat5.1 gene shows a high level of conservation with the single stat5 gene found in other teleosts and lies next to the stat3 gene, in the same relative orientation as the mammalian Stat5b gene [2].
  • In contrast, the stat5.2 gene lies on a different chromosome to stat5.1 and stat3, and has diverged from the stat5 genes of other teleosts, with no apparent orthologue [2].

References

  1. Constitutive activation of zebrafish Stat5 expands hematopoietic cell populations in vivo. Lewis, R.S., Stephenson, S.E., Ward, A.C. Exp. Hematol. (2006) [Pubmed]
  2. Conservation, duplication and divergence of the zebrafish stat5 genes. Lewis, R.S., Ward, A.C. Gene (2004) [Pubmed]
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