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Gene Review

stat3  -  signal transducer and activator of...

Danio rerio

Synonyms: SO:0000704, wu:fc15d02, wu:fl59g06, z-Stat3
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High impact information on stat3

  • 2. The stat5.1 gene shows a high level of conservation with the single stat5 gene found in other teleosts and lies next to the stat3 gene, in the same relative orientation as the mammalian Stat5b gene [1].
  • To understand the evolutionary relationship between d-Stat and vertebrate STATs 3 and 5, we isolated, sequenced, and analyzed the zebrafish Stat3 (z-Stat3) gene and a 500-kb region spanning mouse chromosome 11, 60.5 cM containing three Stat genes (m-Stats) [2].


  1. Conservation, duplication and divergence of the zebrafish stat5 genes. Lewis, R.S., Ward, A.C. Gene (2004) [Pubmed]
  2. Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Miyoshi, K., Cui, Y., Riedlinger, G., Robinson, P., Lehoczky, J., Zon, L., Oka, T., Dewar, K., Hennighausen, L. Genomics (2001) [Pubmed]
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