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Gene Review: 

Sema-5c  -  Semaphorin-5c

Drosophila melanogaster

Synonyms: BEST:CK02567, BG01245, CG5661, CK02567, CT17880, ...
 
 
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Disease relevance of Sema-5c

 

High impact information on Sema-5c

  • In this issue of Neuron, two beautiful studies in Drosophila by Lattemann et al. and Sweeney et al. show that Semaphorin repulsion regulates interactions between olfactory receptor neurons to help axons find their correct targets [2].
  • The activation of the Dpp pathway in l(2)gl tumors occurred only in the presence of Sema-5c [1].
  • Drosophila Sema-5c and the mammalian homologs are transmembrane proteins with extracellular thrombospondin type I (TspI) repeats [1].
  • Expression patterns of two new members of the Semaphorin family in Drosophila suggest early functions during embryogenesis [3].

References

  1. Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype. Woodhouse, E.C., Fisher, A., Bandle, R.W., Bryant-Greenwood, B., Charboneau, L., Petricoin, E.F., Liotta, L.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Semaphorin directs axon traffic in the fly olfactory system. Bashaw, G.J. Neuron (2007) [Pubmed]
  3. Expression patterns of two new members of the Semaphorin family in Drosophila suggest early functions during embryogenesis. Khare, N., Fascetti, N., DaRocha, S., Chiquet-Ehrismann, R., Baumgartner, S. Mech. Dev. (2000) [Pubmed]
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