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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tsp  -  Thrombospondin

Drosophila melanogaster

Synonyms: CG11326, CT31613, D-TSP, DTSP, Dmel\CG11326, ...
 
 
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High impact information on Tsp

  • Drosophila Sema-5c and the mammalian homologs are transmembrane proteins with extracellular thrombospondin type I (TspI) repeats [1].
  • The putative extracellular region contains four tandem repeats of a cysteine-rich motif which is similar to a cysteine pattern present in procollagen and in thrombospondin [2].
  • The open reading frame of the DTSP cDNA encodes a protein that has 1060 amino acid residues [3].
  • Comparison with the genomic sequence revealed that the DTSP gene is divided into 13 exons; The translation initiation site is in exon 2 [3].
  • All of the vectors contain a tsp and a multiple cloning site (MCS) immediately downstream from the hsp26 nurse cell enhancer [4].
 

Other interactions of Tsp

  • The existence of overlapping transcripts was found to be a significant feature of transcription of gene CG11327 and the DTSP gene [5].

References

  1. Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype. Woodhouse, E.C., Fisher, A., Bandle, R.W., Bryant-Greenwood, B., Charboneau, L., Petricoin, E.F., Liotta, L.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development. Schonbaum, C.P., Organ, E.L., Qu, S., Cavener, D.R. Dev. Biol. (1992) [Pubmed]
  3. A thrombospondin homologue in Drosophila melanogaster: cDNA and protein structure. Adolph, K.W. Gene (2001) [Pubmed]
  4. P element transformation vectors for studying Drosophila melanogaster oogenesis and early embryogenesis. Serano, T.L., Cheung, H.K., Frank, L.H., Cohen, R.S. Gene (1994) [Pubmed]
  5. Relationship of transcription of Drosophila melanogaster gene CG11327 and the gene for a thrombospondin homologue (DTSP). Adolph, K.W. DNA Seq. (2001) [Pubmed]
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