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Gene Review

MID1  -  midline 1 (Opitz/BBB syndrome)

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High impact information on MID1

  • The expression of cMid2 overlaps with that of cMid1 in the node, and we demonstrate that MID2 can both mimic MID1 function as a right side determinant and rescue the laterality defects caused by knocking down endogenous MID proteins in the node [1].
  • Here we describe the isolation and characterisation of full-length cDNA clones representing the chick Mid1 gene and the detailed profile of its expression in stage 7 to 28 chick embryos [2].


  1. Evidence of functional redundancy between MID proteins: implications for the presentation of Opitz syndrome. Granata, A., Savery, D., Hazan, J., Cheung, B.M., Lumsden, A., Quaderi, N.A. Dev. Biol. (2005) [Pubmed]
  2. Isolation and characterisation of the chick orthologue of the Opitz syndrome gene, Mid1, supports a conserved role in vertebrate development. Richman, J.M., Fu, K.K., Cox, L.L., Sibbons, J.P., Cox, T.C. Int. J. Dev. Biol. (2002) [Pubmed]
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