The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Mid1  -  midline 1

Rattus norvegicus

Synonyms: E3 ubiquitin-protein ligase Midline-1, Fxy, Midline1, RING finger protein Midline-1, Trim18, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Mid1

 

Psychiatry related information on Mid1

  • Among the administrations of PDG2 by dialysis probes (n = 176), only those (n = 8) to a ventro-rostral part of the basal forebrain by the probes implanted on the midline consistently increased slow-wave sleep (SWS), by 51 +/- 6 min (mean +/- SEM) above the baseline value (111 +/- 11 min) [6].
  • CT and C-6S-PG spread laterally from the midline to the DREZ by Postnatal Day 3, correlating exactly with the end of the critical period [7].
  • Overall, the present results support the idea that the NI is a distinct region of the pontine periventricular gray, and together with the superior central (median raphé) and interpeduncular nuclei the NI appears to form a midline behavior control network of the brainstem [8].
  • 5. Transection of the commissure of Probst produced marked deficits in midline sound localization [9].
  • This zone is likely to act as 1) a chemoattractant for the growth cones of the LRN, ION, and ECN, and 2) a decision-making center, which instructs the somata of these neurons to cross the midline or not, ultimately governing the crossed or uncrossed pattern of their projection to their common target, the cerebellum [10].
 

High impact information on Mid1

  • Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord [11].
  • Floor plate cells at the ventral midline of the neural tube express a diffusible chemoattractant, netrin-1, that attracts a group of ventrally directed axons [12].
  • We demonstrate how commissural interneurons (CINs), whose axons traverse the midline to innervate contralateral neurons, are organized such that distinct flexor and extensor centers in the rostral lumbar spinal cord define activity in both flexor and extensor caudal motor pools [13].
  • We show that the directed circumferential migration of basilar pontine neurons from their origin in the neuroepithelium of the dorsal hindbrain to the ventral midline involves the extension of long (>1 mm) leading processes, which marker analyses suggest are molecularly distinct from axons [14].
  • Here we demonstrate that the ventral midline floor plate (FP) chemorepels two types of ipsilaterally projecting axons, one from the alar plate and another from the basal plate in the mesencephalon [15].
 

Chemical compound and disease context of Mid1

 

Biological context of Mid1

  • Here, we report that the rate of sequence divergence of the 3' end of the Fxy gene is much higher (estimated at 170-fold higher for synonymous sites) when pseudoautosomal (present on both the X and Y chromosomes) than when X-unique [21].
  • METHODS: Male Sprague-Dawley rats underwent a midline laparotomy (i.e., soft-tissue trauma induced) and were then bled to and maintained at a mean arterial pressure of 40 mmHg until 40% of the maximal shed blood volume was returned in the form of Ringer's lactate [22].
  • Activated Neu expression in the midline glia suppressed apoptosis, similar to that seen with activated Drosophila EGF-R expression [23].
  • However, sequencing PAR and non-PAR introns of the Fxy gene in four Mus taxa, we found an increase of only twofold to fivefold [24].
  • Taken together, these results suggest that 5-HT(7) receptors are implicated in the effect of 5-HT on sAHP in intralaminar and midline thalamic neurones, an effect that is mediated by the cAMP second-messenger cascade [25].
 

Anatomical context of Mid1

 

Associations of Mid1 with chemical compounds

  • Rat pups were reared to P12, at which time glass pins coated with 1, 1'-dioctodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate were placed in fixed tissue in the commissure of Probst where DNLL fibers cross the midline [31].
  • The neurochemical identities of afferents to the midline thalamus were investigated in chloral hydrate-anesthetized adult Sprague-Dawley rats [32].
  • A molecule which is unique to the roof plate when axons grow close to, but do not cross, the dorsal midline is a glycosaminoglycan (GAG), keratan sulfate [33].
  • Furthermore, pathologic changes in the mammillary and several midline intralaminar nuclei begin after thiamine administration and reinstitution of thiamine-replete diet to animals in more severe stages of thiamine deficiency [34].
  • Serotonin suppresses the slow afterhyperpolarization in rat intralaminar and midline thalamic neurones by activating 5-HT(7) receptors [25].
 

Physical interactions of Mid1

 

Regulatory relationships of Mid1

  • We show that during the initial appearance and subsequent maturation of OPCs, BMP4 was expressed specifically in the dorsal midline and its expression was correlated spatially and temporally with phospho-Smad 1+, BMP4-responsive cells [36].
  • In the adult rat thalamus, calretinin immunoreactivity is intensely expressed in some intralaminar and midline nuclei, as well as in selected regions of the reticular nucleus [37].
  • The results reported here show that closely related members of the HNF-3/fork head gene family are expressed by axial midline cell groups involved in neural induction and patterning and suggest the involvement of these genes in the development of the vertebrate neuraxis [38].
  • Vimentin expression was not detected in the MEE prior to rotation but was specifically upregulated in the MEE following rotation and prior to midline contact and continued in the MES and in epithelial cells identifiable during the breakdown of the MES [39].
 

Other interactions of Mid1

  • The PYY probe hybridized with two populations of neurons in the brainstem: one dispersed along the midline in the rostral medulla and another in the lateral caudal medulla (A1 region) [40].
  • NR2D mRNA localized exclusively to those diencephalic nuclei that have a fourth, distinct pharmacological profile (typified by the midline thalamic nuclei) [41].
  • High expression of mGluR1 mRNA mainly occurred in midline nuclei such as the centromedial/centrolateral (CM/CL) nuclei, parafascicular and submedius nuclei, and in the ventroposteromedial (VPM) and posterior (Po) nuclei [42].
  • This quantitative increase was first apparent in the midline structures and then in the other thalamic territories which are CB-positive in adulthood, and followed a mediolateral gradient [43].
  • Prenatal exposure to selective COX-2 inhibitors does not increase the risk of ventricular septal and midline defects in rat when compared to non-selective drugs and historic control [44].
 

Analytical, diagnostic and therapeutic context of Mid1

  • During the fusion of rodent embryo palatal shelves, the cells of the outer epithelial layer slough off, allowing the cells of the medial edge basal layer to form a midline seam that undergoes epithelial-mesenchymal transformation, as judged by electron microscopy and immunohistochemistry [45].
  • Rats (n = 12; 270 to 300 g) were lightly anesthetized with ether and a 6-cm midline laparotomy performed (i.e., trauma induced) [46].
  • Neuroanatomically in the spinal cord, a significant increase of midline crossing corticospinal fibers originating in the unlesioned sensorimotor cortex was found in 7B12-treated groups, reaching 2.3 +/- 1.5% after PCI (control group: 1.1 +/- 0.5%) and 4.5 +/- 2.2% after MCAO in SHR rats (control group: 1.8 +/- 0.8%) [47].
  • In contrast, electrical stimulation of the midline (interstitial nucleus of the medial longitudinal fasciculus) 1 mm medial to the DMRF did not change CBF [48].
  • By in situ hybridization analysis we show that transitin mRNA is expressed by midline radial glial structures, by several axon commissures, and by Bergmann glia of the developing cerebelium [49].

References

  1. RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-gamma. Tjuvajev, J., Gansbacher, B., Desai, R., Beattie, B., Kaplitt, M., Matei, C., Koutcher, J., Gilboa, E., Blasberg, R. Cancer Res. (1995) [Pubmed]
  2. The prevention of incisional hernia formation using a delayed-release polymer of basic fibroblast growth factor. Dubay, D.A., Wang, X., Kuhn, M.A., Robson, M.C., Franz, M.G. Ann. Surg. (2004) [Pubmed]
  3. Effects of fluid management on edema volume and midline shift in a rat model of ischemic stroke. Paczynski, R.P., Venkatesan, R., Diringer, M.N., He, Y.Y., Hsu, C.Y., Lin, W. Stroke (2000) [Pubmed]
  4. Central sensitization as a result of surgical pain: investigation of the pre-emptive value of pethidine for ovariohysterectomy in the rat. Lascelles, B.D., Waterman, A.E., Cripps, P.J., Livingston, A., Henderson, G. Pain (1995) [Pubmed]
  5. The dorsal column pathway facilitates visceromotor responses to colorectal distention after colon inflammation in rats. Palecek, J., Willis, W.D. Pain (2003) [Pubmed]
  6. Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. Matsumura, H., Nakajima, T., Osaka, T., Satoh, S., Kawase, K., Kubo, E., Kantha, S.S., Kasahara, K., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Putative inhibitory extracellular matrix molecules at the dorsal root entry zone of the spinal cord during development and after root and sciatic nerve lesions. Pindzola, R.R., Doller, C., Silver, J. Dev. Biol. (1993) [Pubmed]
  8. Connections of the nucleus incertus. Goto, M., Swanson, L.W., Canteras, N.S. J. Comp. Neurol. (2001) [Pubmed]
  9. Sound localization after transection of the commissure of Probst in the albino rat. Ito, M., van Adel, B., Kelly, J.B. J. Neurophysiol. (1996) [Pubmed]
  10. Migratory pathways and selective aggregation of the lateral reticular neurons in the rat embryo: a horseradish peroxidase in vitro study, with special reference to migration patterns of the precerebellar nuclei. Bourrat, F., Sotelo, C. J. Comp. Neurol. (1990) [Pubmed]
  11. Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Zou, Y., Stoeckli, E., Chen, H., Tessier-Lavigne, M. Cell (2000) [Pubmed]
  12. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Colamarino, S.A., Tessier-Lavigne, M. Cell (1995) [Pubmed]
  13. Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals. Butt, S.J., Kiehn, O. Neuron (2003) [Pubmed]
  14. Extension of long leading processes and neuronal migration in the mammalian brain directed by the chemoattractant netrin-1. Yee, K.T., Simon, H.H., Tessier-Lavigne, M., O'Leary, D.M. Neuron (1999) [Pubmed]
  15. Floor plate chemoattracts crossed axons and chemorepels uncrossed axons in the vertebrate brain. Tamada, A., Shirasaki, R., Murakami, F. Neuron (1995) [Pubmed]
  16. Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage. Yokoyama, Y., Kitchens, W.C., Toth, B., Schwacha, M.G., Rue, L.W., Bland, K.I., Chaudry, I.H. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  17. Haemorrhage-evoked compensation and decompensation are mediated by distinct caudal midline medullary regions in the urethane-anaesthetised rat. Heslop, D.J., Keay, K.A., Bandler, R. Neuroscience (2002) [Pubmed]
  18. Identification of a median thalamic system regulating seizures and arousal. Miller, J.W., Hall, C.M., Holland, K.D., Ferrendelli, J.A. Epilepsia (1989) [Pubmed]
  19. An ascending seizure-controlling pathway in the medial brainstem and thalamus. Miller, J.W., Gray, B.C., Turner, G.M., Bardgett, M.E. Exp. Neurol. (1993) [Pubmed]
  20. Caudal midline medulla mediates behaviourally-coupled but not baroreceptor-mediated vasodepression. Henderson, L.A., Keay, K.A., Bandler, R. Neuroscience (2000) [Pubmed]
  21. Evolutionary rate of a gene affected by chromosomal position. Perry, J., Ashworth, A. Curr. Biol. (1999) [Pubmed]
  22. Inhibition of tyrosine kinase signaling after trauma-hemorrhage: a novel approach for improving organ function and decreasing susceptibility to subsequent sepsis. Jarrar, D., Wang, P., Song, G.Y., Cioffi, W.G., Bland, K.I., Chaudry, I.H. Ann. Surg. (2000) [Pubmed]
  23. Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model. Settle, M., Gordon, M.D., Nadella, M., Dankort, D., Muller, W., Jacobs, J.R. Oncogene (2003) [Pubmed]
  24. How strong is the mutagenicity of recombination in mammals? Huang, S.W., Friedman, R., Yu, N., Yu, A., Li, W.H. Mol. Biol. Evol. (2005) [Pubmed]
  25. Serotonin suppresses the slow afterhyperpolarization in rat intralaminar and midline thalamic neurones by activating 5-HT(7) receptors. Goaillard, J.M., Vincent, P. J. Physiol. (Lond.) (2002) [Pubmed]
  26. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Kennedy, T.E., Serafini, T., de la Torre, J.R., Tessier-Lavigne, M. Cell (1994) [Pubmed]
  27. Targeting of secretory vesicles to cytoplasmic domains in AtT-20 and PC-12 cells. Matsuuchi, L., Buckley, K.M., Lowe, A.W., Kelly, R.B. J. Cell Biol. (1988) [Pubmed]
  28. Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies. Bloom, F., Battenberg, E., Rossier, J., Ling, N., Guillemin, R. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  29. Quantitative autoradiographic localization of [3H]imipramine binding sites in the brain of the rat: relationship to ascending 5-hydroxytryptamine neuron systems. Fuxe, K., Calza, L., Benfenati, F., Zini, I., Agnati, L.F. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  30. Changes in local cerebral glucose utilization during rewarding brain stimulation. Esposito, R.U., Porrino, L.J., Seeger, T.F., Crane, A.M., Everist, H.D., Pert, A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  31. Plasticity in the development of afferent patterns in the inferior colliculus of the rat after unilateral cochlear ablation. Gabriele, M.L., Brunso-Bechtold, J.K., Henkel, C.K. J. Neurosci. (2000) [Pubmed]
  32. Monoamines and nitric oxide are employed by afferents engaged in midline thalamic regulation. Otake, K., Ruggiero, D.A. J. Neurosci. (1995) [Pubmed]
  33. Molecular and cellular characterization of the glial roof plate of the spinal cord and optic tectum: a possible role for a proteoglycan in the development of an axon barrier. Snow, D.M., Steindler, D.A., Silver, J. Dev. Biol. (1990) [Pubmed]
  34. Excitotoxic cytopathology, progression, and reversibility of thiamine deficiency-induced diencephalic lesions. Zhang, S.X., Weilersbacher, G.S., Henderson, S.W., Corso, T., Olney, J.W., Langlais, P.J. J. Neuropathol. Exp. Neurol. (1995) [Pubmed]
  35. Discrete localization of high-density 5-HT1A binding sites in the midline raphe and parapyramidal region of the ventral medulla oblongata of the rat. Thor, K.B., Blitz-Siebert, A., Helke, C.J. Neurosci. Lett. (1990) [Pubmed]
  36. Patterning of spinal cord oligodendrocyte development by dorsally derived BMP4. Miller, R.H., Dinsio, K., Wang, R., Geertman, R., Maier, C.E., Hall, A.K. J. Neurosci. Res. (2004) [Pubmed]
  37. Calretinin immunoreactivity in the developing thalamus of the rat: a marker of early generated thalamic cells. Frassoni, C., Arcelli, P., Selvaggio, M., Spreafico, R. Neuroscience (1998) [Pubmed]
  38. Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate. Ruiz i Altaba, A., Prezioso, V.R., Darnell, J.E., Jessell, T.M. Mech. Dev. (1993) [Pubmed]
  39. Midline fusion in the formation of the secondary palate anticipated by upregulation of keratin K5/6 and localized expression of vimentin mRNA in medial edge epithelium. Gibbins, J.R., Manthey, A., Tazawa, Y.M., Scott, B., Bloch-Zupan, A., Hunter, N. Int. J. Dev. Biol. (1999) [Pubmed]
  40. Differential expression of mRNAs for neuropeptide Y-related peptides in rat nervous tissues: possible evolutionary conservation. Pieribone, V.A., Brodin, L., Friberg, K., Dahlstrand, J., Söderberg, C., Larhammar, D., Hökfelt, T. J. Neurosci. (1992) [Pubmed]
  41. The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition. Buller, A.L., Larson, H.C., Schneider, B.E., Beaton, J.A., Morrisett, R.A., Monaghan, D.T. J. Neurosci. (1994) [Pubmed]
  42. Differential distribution of metabotropic glutamate receptor subtype mRNAs in the thalamus of the rat. Lourenço Neto, F., Schadrack, J., Berthele, A., Zieglgänsberger, W., Tölle, T.R., Castro-Lopes, J.M. Brain Res. (2000) [Pubmed]
  43. Postnatal development of calbindin and parvalbumin immunoreactivity in the thalamus of the rat. Frassoni, C., Bentivoglio, M., Spreafico, R., Sánchez, M.P., Puelles, L., Fairen, A. Brain Res. Dev. Brain Res. (1991) [Pubmed]
  44. Comparison of developmental toxicity of selective and non-selective cyclooxygenase-2 inhibitors in CRL:(WI)WUBR Wistar rats--DFU and piroxicam study. Burdan, F. Toxicology (2005) [Pubmed]
  45. Epithelial-mesenchymal transformation during palatal fusion: carboxyfluorescein traces cells at light and electron microscopic levels. Griffith, C.M., Hay, E.D. Development (1992) [Pubmed]
  46. Depressed gut absorptive capacity early after trauma-hemorrhagic shock. Restoration with diltiazem treatment. Singh, G., Chaudry, K.I., Chudler, L.C., Chaudry, I.H. Ann. Surg. (1991) [Pubmed]
  47. Anti-Nogo-A antibody infusion 24 hours after experimental stroke improved behavioral outcome and corticospinal plasticity in normotensive and spontaneously hypertensive rats. Wiessner, C., Bareyre, F.M., Allegrini, P.R., Mir, A.K., Frentzel, S., Zurini, M., Schnell, L., Oertle, T., Schwab, M.E. J. Cereb. Blood Flow Metab. (2003) [Pubmed]
  48. Global cerebral vasodilatation elicited by focal electrical stimulation within the dorsal medullary reticular formation in anesthetized rat. Iadecola, C., Nakai, M., Arbit, E., Reis, D.J. J. Cereb. Blood Flow Metab. (1983) [Pubmed]
  49. Molecular cloning of a new intermediate filament protein expressed by radial glia and demonstration of alternative splicing in a novel heptad repeat region located in the carboxy-terminal tail domain. Yuan, Y., Lee, J.A., Napier, A., Cole, G.J. Mol. Cell. Neurosci. (1997) [Pubmed]
 
WikiGenes - Universities