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Gene Review

HPSE  -  heparanase

Gallus gallus

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Disease relevance of HPSE

  • Cloning and characterization of heparanase, the first and single functional vertebrate HS-degrading enzyme, may lead to identification of other glycosaminoglycan degrading enzymes, toward elucidation of their significance in normal and pathological processes [1].

High impact information on HPSE

  • CRF or isolation alone slightly activated the HPA axis, whereas CRF plus isolation greatly increased corticosterone levels except in the LSR line [2].


  1. Expression pattern and secretion of human and chicken heparanase are determined by their signal peptide sequence. Goldshmidt, O., Zcharia, E., Aingorn, H., Guatta-Rangini, Z., Atzmon, R., Michal, I., Pecker, I., Mitrani, E., Vlodavsky, I. J. Biol. Chem. (2001) [Pubmed]
  2. Effects of CRF on isolated Japanese quails selected for fearfulness and for sociality. Launay, F., Mills, A.D., Faure, J.M., Williams, J.B. Physiol. Behav. (1993) [Pubmed]
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