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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HIRA  -  histone cell cycle regulator

Gallus gallus

 
 
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Disease relevance of HIRA

 

High impact information on HIRA

  • We have cloned the chick homologue of HIRA and conducted in situ expression analysis in early chick embryos [1].
  • Hira is expressed in the developing neural plate, the neural tube, neural crest and the mesenchyme of the head and branchial arch structures [1].
  • Moreover, the WD dipeptide motifs and LXXLL motif of HIRA are essential for the interaction with CAF-1p48 and HDAC-2 in vivo [2].
 

Biological context of HIRA

 

Analytical, diagnostic and therapeutic context of HIRA

  • The immunoprecipitation experiment involving truncated and missense mutants of HIRA and CAF-1p48 revealed not only that even one of seven WD dipeptide motifs in the N-terminal half of HIRA are necessary for the interaction with CAF-1p48, but also that those of CAF-1p48 are necessary for the interaction with HIRA [2].

References

  1. Cloning and developmental expression analysis of chick Hira (Chira), a candidate gene for DiGeorge syndrome. Roberts, C., Daw, S.C., Halford, S., Scambler, P.J. Hum. Mol. Genet. (1997) [Pubmed]
  2. WD dipeptide motifs and LXXLL motif of chicken HIRA are essential for interactions with the p48 subunit of chromatin assembly factor-1 and histone deacetylase-2 in vitro and in vivo. Ahmad, A., Takami, Y., Nakayama, T. Gene (2004) [Pubmed]
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