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Gene Review

GIT1  -  G protein-coupled receptor kinase...

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High impact information on GIT1

  • ADP-ribosylation factor GTPase-activating proteins (ARFGAPs) of the G-protein-coupled receptor kinase interactor 1/p95 paxillin kinase linker/p95-ARFGAP Pak-interacting exchange factor paxillin-binding protein (APP)-1 family are multidomain proteins, which interact functionally with both ARF and Rac GTPases [1].
  • Our findings show the specific localization of the complex at intracellular membranes, and indicate a correlation between the association of GIT1 to betaPIX, and the localization of the endogenous complex at membranes [2].


  1. Leucine-zipper-mediated homo- and hetero-dimerization of GIT family p95-ARF GTPase-activating protein, PIX-, paxillin-interacting proteins 1 and 2. Paris, S., Longhi, R., Santambrogio, P., de Curtis, I. Biochem. J. (2003) [Pubmed]
  2. Characterization of the endogenous GIT1-betaPIX complex, and identification of its association to membranes. Botrugno, O.A., Paris, S., Za, L., Gualdoni, S., Cattaneo, A., Bachi, A., de Curtis, I. Eur. J. Cell Biol. (2006) [Pubmed]
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