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Gene Review

PXN  -  paxillin

Gallus gallus

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Disease relevance of PXN

  • Together with the previous observation that paxillin is a major substrate of pp60src in Rous sarcoma virus-transformed cells (Glenney, J. R., and L. Zokas. 1989. J. Cell Biol. 108:2401-2408), this interaction with vinculin suggests paxillin may be a key component in the control of focal adhesion organization [1].
  • To determine whether increased FAK and paxillin protein concentrations are associated with hypertrophy and/or new fiber formation, two additional experiments were performed [2].
  • Second, FAK (112% and 611%) and paxillin (87% and 431%) protein concentrations per unit of total protein in the soleus muscle increased at 1 and 8 days after surgical ablation of the synergistic gastrocnemius muscle (a model of hypertrophy without hyperplasia) [2].

High impact information on PXN


Biological context of PXN


Anatomical context of PXN


Associations of PXN with chemical compounds


Other interactions of PXN


Analytical, diagnostic and therapeutic context of PXN

  • The levels of plasma catecholamines were measured by high-performance liquid chromatograpy (HPLC) and indicated a different effect with PSP, which causes OPIDN, and PXN, which does not [11].
  • FAK (77 and 81%) and paxillin (206 and 202%) protein concentrations per unit of total protein in Western blots increased significantly after 1.5 and 7 days, but not after 13 days, of stretch-induced hypertrophy-hyperplasia of the ALD muscle [2].


  1. Paxillin: a new vinculin-binding protein present in focal adhesions. Turner, C.E., Glenney, J.R., Burridge, K. J. Cell Biol. (1990) [Pubmed]
  2. Focal adhesion proteins FAK and paxillin increase in hypertrophied skeletal muscle. Flück, M., Carson, J.A., Gordon, S.E., Ziemiecki, A., Booth, F.W. Am. J. Physiol. (1999) [Pubmed]
  3. Integrin and cadherin synergy regulates contact inhibition of migration and motile activity. Huttenlocher, A., Lakonishok, M., Kinder, M., Wu, S., Truong, T., Knudsen, K.A., Horwitz, A.F. J. Cell Biol. (1998) [Pubmed]
  4. Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells. Mueller, S.C., Yeh, Y., Chen, W.T. J. Cell Biol. (1992) [Pubmed]
  5. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. Bellis, S.L., Miller, J.T., Turner, C.E. J. Biol. Chem. (1995) [Pubmed]
  6. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. Salgia, R., Li, J.L., Lo, S.H., Brunkhorst, B., Kansas, G.S., Sobhany, E.S., Sun, Y., Pisick, E., Hallek, M., Ernst, T. J. Biol. Chem. (1995) [Pubmed]
  7. Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Birge, R.B., Fajardo, J.E., Reichman, C., Shoelson, S.E., Songyang, Z., Cantley, L.C., Hanafusa, H. Mol. Cell. Biol. (1993) [Pubmed]
  8. Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development. Tang, D.D., Turner, C.E., Gunst, S.J. J. Physiol. (Lond.) (2003) [Pubmed]
  9. Effect of cyclic phenyl saligenin phosphate and paraoxon treatment on vascular response to adrenergic and cholinergic agents in hens. McCain, W.C., Wilcke, J., Lee, J.C., Ehrich, M. Journal of toxicology and environmental health. (1995) [Pubmed]
  10. Localization of paxillin, a focal adhesion protein, to smooth muscle dense plaques, and the myotendinous and neuromuscular junctions of skeletal muscle. Turner, C.E., Kramarcy, N., Sealock, R., Burridge, K. Exp. Cell Res. (1991) [Pubmed]
  11. Catecholamine concentrations and contractile responses of isolated vessels from hens treated with cyclic phenyl saligenin phosphate or paraoxon in the presence or absence of verapamil. McCain, W.C., Flaherty, D.M., Correll, L., Jortner, B., Ehrich, M. Journal of toxicology and environmental health. (1996) [Pubmed]
  12. Chick sensory neuronal growth cones distinguish fibronectin from laminin by making substratum contacts that resemble focal contacts. Gomez, T.M., Roche, F.K., Letourneau, P.C. J. Neurobiol. (1996) [Pubmed]
  13. Inhibition of focal adhesion kinase expression correlates with changes in the cytoskeleton but not apoptosis in primary cultures of chick embryo cells. Ridyard, M.S., Sanders, E.J. Cell Biol. Int. (2001) [Pubmed]
  14. v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts. Fincham, V.J., Wyke, J.A., Frame, M.C. Oncogene (1995) [Pubmed]
  15. Leucine-zipper-mediated homo- and hetero-dimerization of GIT family p95-ARF GTPase-activating protein, PIX-, paxillin-interacting proteins 1 and 2. Paris, S., Longhi, R., Santambrogio, P., de Curtis, I. Biochem. J. (2003) [Pubmed]
  16. Association of focal adhesion kinase with fibronectin and paxillin is required for precartilage condensation of chick mesenchymal cells. Bang, O.S., Kim, E.J., Chung, J.G., Lee, S.R., Park, T.K., Kang, S.S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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