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Gene Review

PSEN2  -  presenilin 2 (Alzheimer disease 4)

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High impact information on PSEN2

  • Here we show mRNA and protein expression of PS1 in both lymphoid and myeloid cells, while PS2 mRNA is present only in lymphocytes [1].
  • Simultaneous testing of cell lysates from isolates W50, PS2, and PS5 and nicotine resulted in a percentage kill significantly greater than expected (Fisher's Exact test) [2].


  1. Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules. Mirinics, Z.K., Calafat, J., Udby, L., Lovelock, J., Kjeldsen, L., Rothermund, K., Sisodia, S.S., Borregaard, N., Corey, S.J. Blood Cells Mol. Dis. (2002) [Pubmed]
  2. Possible lethal enhancement of toxins from putative periodontopathogens by nicotine: implications for periodontal disease. Sayers, N.M., Gomes, B.P., Drucker, D.B., Blinkhorn, A.S. J. Clin. Pathol. (1997) [Pubmed]
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