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Gene Review

Psen2  -  presenilin 2

Rattus norvegicus

Synonyms: PS-2, Presenilin-2, Ps2, Psnl2
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Disease relevance of Psen2


Psychiatry related information on Psen2


High impact information on Psen2


Biological context of Psen2

  • RESULTS: IK was increased in cultured rat hippocampal neurons, after transient transfection of PS-1, PS-2, and APP695 [5].

Anatomical context of Psen2


Associations of Psen2 with chemical compounds

  • PS2 was much more inhibited during propofol-induced sleep, than during the pretreatment period, consistent with an expected marked increase in recurrent inhibition [8].
  • Sevoflurane 2.0 vol% significantly enhanced paired-pulse (PS2/PS1) facilitation (from 128.4% to 155.5% at an inter-stimulus interval of 37.9 ms); this enhancement was blocked by phaclofen [9].
  • At higher stimulation intensities, however, baclofen (30 mg/kg iv) increased PS2, while barely affecting the population spike in BIC-treated animals [10].

Regulatory relationships of Psen2


Analytical, diagnostic and therapeutic context of Psen2

  • RT-PCR confirmed the presence of PS2 in the heart of adult rats.Using quantitative real-time RT-PCR, we further studied the expression of presenilin-2 mRNA under conditions of low oxygen supply and glucose starvation [1].


  1. Presenilins in the heart: presenilin-2 expression is increased by low glucose and by hypoxia in cardiac cells. Mohuczy, D., Qian, K., Phillips, M.I. Regul. Pept. (2002) [Pubmed]
  2. The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis. Cai, C., Lin, P., Cheung, K.H., Li, N., Levchook, C., Pan, Z., Ferrante, C., Boulianne, G.L., Foskett, J.K., Danielpour, D., Ma, J. J. Biol. Chem. (2006) [Pubmed]
  3. Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain. Beher, D., Elle, C., Underwood, J., Davis, J.B., Ward, R., Karran, E., Masters, C.L., Beyreuther, K., Multhaup, G. J. Neurochem. (1999) [Pubmed]
  4. Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats. Ricceri, L., Minghetti, L., Moles, A., Popoli, P., Confaloni, A., De Simone, R., Piscopo, P., Scattoni, M.L., di Luca, M., Calamandrei, G. Exp. Neurol. (2004) [Pubmed]
  5. Effects of presenilins and beta-amyloid precursor protein on delayed rectifier potassium channels in cultured rat hippocampal neurons. Zhang, W., Jin, H.W., Wang, X.L. Acta Pharmacol. Sin. (2004) [Pubmed]
  6. Repression of somatostatin gene transcription mediated by two promoter silencer elements. Vallejo, M., Miller, C.P., Beckman, W., Habener, J.F. Mol. Cell. Endocrinol. (1995) [Pubmed]
  7. Mutant presenilin 2 increases acetylcholinesterase activity in neuronal cells. Nguyen, H.N., Hwang, D.Y., Kim, Y.K., Yoon, d.o. .Y., Kim, J.H., Lee, M.S., Lee, M.K., Yun, Y.P., Oh, K.W., Hong, J.T. Arch. Pharm. Res. (2005) [Pubmed]
  8. The short-acting anesthetic propofol produces biphasic effects-depression and withdrawal rebound overshoot-on some (but not all) limbic evoked potentials in the behaving rat. Hasan, Z.A., Woolley, D.E. Brain Res. (1999) [Pubmed]
  9. Sevoflurane modulates both GABAA and GABAB receptors in area CA1 of rat hippocampus. Hirota, K., Roth, S.H. British journal of anaesthesia. (1997) [Pubmed]
  10. Input-output dependence reveals the components of GABAergic modulation in rat hippocampal CA3 in vivo. Margineanu, D.G., Wülfert, E. Arch. Physiol. Biochem. (1995) [Pubmed]
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