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Gene Review

Psen2  -  presenilin 2

Mus musculus

Synonyms: AI266870, ALG-3, Ad4h, Alg3, PS-2, ...
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Disease relevance of Psen2

  • Both mechanisms by M239V-PS2 were suppressed by pertussis toxin (PTX) and were mediated by Galpha(o), but not by Galpha(i) [1].
  • Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis [2].
  • Nonetheless, these results collectively suggest that the novel PS-2 alleles described here, especially R71W, affect PS-2 function and may potentially confer a moderate risk of susceptibility to breast cancer [3].
  • Two dominant fractions, designated as PS-1 and PS-2, were tested for adjuvant activity in mice immunized with ovalbumin, and hens immunized with rotavirus [4].

Psychiatry related information on Psen2


High impact information on Psen2


Chemical compound and disease context of Psen2


Biological context of Psen2


Anatomical context of Psen2

  • We investigated the impact of PS/gamma-secretase on mitochondrial function using mouse embryonal fibroblasts derived from wild-type, PS1-/-, PS2-/- and PS double knock-out (PSKO) embryos [14].
  • Measurements of mitochondrial membrane potential (DeltaPsim) showed a higher percentage of fully functional mitochondria in PS1-/- and PSwt as compared to PS2-/- and PSKO cells [14].
  • PS2-/- cells showed a significantly lower basal respiratory rate as compared to other cell lines [14].
  • Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus [15].
  • Decreases in activities of the NF-kappaB, AP-1 and SP-1 transcription factors, which could act as antiapoptotic factors, in the presenilin 2 transfected PC12 cells, either in nontreatment conditions or under apoptotic stimulation, were found in this study [16].

Associations of Psen2 with chemical compounds


Other interactions of Psen2


  1. Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant. Abe, Y., Hashimoto, Y., Tomita, Y., Terashita, K., Aiso, S., Tajima, H., Niikura, T., Matsuoka, M., Nishimoto, I. J. Neurosci. Res. (2004) [Pubmed]
  2. Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis. Carro, E., Trejo, J.L., Gerber, A., Loetscher, H., Torrado, J., Metzger, F., Torres-Aleman, I. Neurobiol. Aging (2006) [Pubmed]
  3. Functional characterization of novel presenilin-2 variants identified in human breast cancers. To, M.D., Gokgoz, N., Doyle, T.G., Donoviel, D.B., Knight, J.A., Hyslop, P.S., Bernstein, A., Andrulis, I.L. Oncogene (2006) [Pubmed]
  4. Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L. Estrada, A., Katselis, G.S., Laarveld, B., Barl, B. Comp. Immunol. Microbiol. Infect. Dis. (2000) [Pubmed]
  5. Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease. Lopez-Lopez, C., Dietrich, M.O., Metzger, F., Loetscher, H., Torres-Aleman, I. J. Neurosci. (2007) [Pubmed]
  6. Presenilins Form ER Ca(2+) Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations. Tu, H., Nelson, O., Bezprozvanny, A., Wang, Z., Lee, S.F., Hao, Y.H., Serneels, L., De Strooper, B., Yu, G., Bezprozvanny, I. Cell (2006) [Pubmed]
  7. Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Vito, P., Lacanà, E., D'Adamio, L. Science (1996) [Pubmed]
  8. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Feng, R., Wang, H., Wang, J., Shrom, D., Zeng, X., Tsien, J.Z. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. Chen, F., Tandon, A., Sanjo, N., Gu, Y.J., Hasegawa, H., Arawaka, S., Lee, F.J., Ruan, X., Mastrangelo, P., Erdebil, S., Wang, L., Westaway, D., Mount, H.T., Yankner, B., Fraser, P.E., St George-Hyslop, P. J. Biol. Chem. (2003) [Pubmed]
  10. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. Vito, P., Ghayur, T., D'Adamio, L. J. Biol. Chem. (1997) [Pubmed]
  11. Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3. Vito, P., Wolozin, B., Ganjei, J.K., Iwasaki, K., Lacanà, E., D'Adamio, L. J. Biol. Chem. (1996) [Pubmed]
  12. Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation. Lee, S.M., Lee, J.W., Song, Y.S., Hwang, D.Y., Kim, Y.K., Nam, S.Y., Kim, D.J., Yun, Y.W., Yoon, d.o. .Y., Hong, J.T. J. Neurosci. Res. (2005) [Pubmed]
  13. Functional cloning of genes involved in T-cell receptor-induced programmed cell death. D'Adamio, L., Lacanà, E., Vito, P. Semin. Immunol. (1997) [Pubmed]
  14. Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts. Behbahani, H., Shabalina, I.G., Wiehager, B., Concha, H., Hultenby, K., Petrovic, N., Nedergaard, J., Winblad, B., Cowburn, R.F., Ankarcrona, M. J. Neurosci. Res. (2006) [Pubmed]
  15. Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus. Apert, C., Czech, C., Faivre-Bauman, A., Loudes, C., Pradier, L., Epelbaum, J. J. Neuroendocrinol. (1998) [Pubmed]
  16. Decrease in NF-kappaB, AP-1 and SP-1 activities in neuronal cells expressing presenilin 2. Nguyen, H.N., Lee, S.Y., Hwang, D.Y., Kim, Y.K., Yuk, D.Y., Lee, J.S., Hong, J.T. Neuroreport (2005) [Pubmed]
  17. Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2. Hashimoto, Y., Niikura, T., Ito, Y., Kita, Y., Terashita, K., Nishimoto, I. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  18. Changes in presenilin 2-binding Wnt proteins, behavior, amyloid-beta 42, gamma-secretase activity, and testosterone sensitivity in transgenic mice coexpressing tetracycline-controlled transactivator and human mutant presenilin 2. Hwang, D.Y., Cho, J.S., Kim, C.K., Shim, S.B., Jee, S.W., Lee, S.H., Seo, S.J., Choi, S.Y., Kim, Y.K. Neuromolecular Med. (2006) [Pubmed]
  19. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. Lai, M.T., Chen, E., Crouthamel, M.C., DiMuzio-Mower, J., Xu, M., Huang, Q., Price, E., Register, R.B., Shi, X.P., Donoviel, D.B., Bernstein, A., Hazuda, D., Gardell, S.J., Li, Y.M. J. Biol. Chem. (2003) [Pubmed]
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