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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CRHR1  -  corticotropin releasing hormone receptor 1

Gallus gallus

 
 
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High impact information on CRHR1

  • Co-injection of a CRF receptor antagonist, astressin, attenuated ghrelin-induced plasma corticosterone increase and anorexia [1].
  • In contrast, the levels of CRF peptide in the hypothalamic area, the CRF receptor type 1 (CRF-R1) mRNA and pro-opiomelanocortin (POMC) mRNA levels in the pituitary were not affected by the in vivo administration of corticosterone [2].
  • Possibly CRH-induced TSH secretion is mediated by a yet unknown type of CRH-R in the chicken [3].
  • This effect was partly attenuated by co-injection of astressin, a CRF receptor antagonist, demonstrating that alpha-MSH stimulated CORT secretion by activating CRF neurons [4].
  • The CORT-releasing effect was partly attenuated by co-injection of astressin, a CRF receptor antagonist, demonstrating that GLP-1 stimulated CORT secretion by activation of CRF neurons [5].

References

  1. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Saito, E.S., Kaiya, H., Tachibana, T., Tomonaga, S., Denbow, D.M., Kangawa, K., Furuse, M. Regul. Pept. (2005) [Pubmed]
  2. Corticosterone-induced negative feedback mechanisms within the hypothalamo-pituitary-adrenal axis of the chicken. Vandenborne, K., De Groef, B., Geelissen, S.M., Kühn, E.R., Darras, V.M., Van der Geyten, S. J. Endocrinol. (2005) [Pubmed]
  3. Involvement of thyrotropin-releasing hormone receptor, somatostatin receptor subtype 2 and corticotropin-releasing hormone receptor type 1 in the control of chicken thyrotropin secretion. De Groef, B., Geris, K.L., Manzano, J., Bernal, J., Millar, R.P., Abou-Samra, A.B., Porter, T.E., Iwasawa, A., Kühn, E.R., Darras, V.M. Mol. Cell. Endocrinol. (2003) [Pubmed]
  4. The anorexic effect of alpha-melanocyte-stimulating hormone is mediated by corticotrophin-releasing factor in chicks. Tachibana, T., Oikawa, D., Takahashi, H., Boswell, T., Furuse, M. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2007) [Pubmed]
  5. Involvement of CRF on the anorexic effect of GLP-1 in layer chicks. Tachibana, T., Sato, M., Oikawa, D., Furuse, M. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2006) [Pubmed]
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