Gene Review:
Crhr1 - corticotropin releasing hormone receptor 1
Mus musculus
Synonyms:
CRF 1 receptor, CRF-R-1, CRF-R1, CRF-R1alpha, CRFR-1, ...
- Modulation of urocortin-induced hypophagia and weight loss by corticotropin-releasing factor receptor 1 deficiency in mice. Bradbury, M.J., McBurnie, M.I., Denton, D.A., Lee, K.F., Vale, W.W. Endocrinology (2000)
- Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: a potential link to microglia and atrocytes that express CRH-R1. Stevens, S.L., Shaw, T.E., Dykhuizen, E., Lessov, N.S., Hill, J.K., Wurst, W., Stenzel-Poore, M.P. J. Cereb. Blood Flow Metab. (2003)
- Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides. Brar, B.K., Chen, A., Perrin, M.H., Vale, W. Endocrinology (2004)
- Corticotropin-releasing factor receptor 1-deficient mice do not develop postoperative gastric ileus. Luckey, A., Wang, L., Jamieson, P.M., Basa, N.R., Million, M., Czimmer, J., Vale, W., Taché, Y. Gastroenterology (2003)
- Corticotropin-releasing factor stimulates phospholipid methylation and corticotropin secretion in mouse pituitary tumor cells. Hook, V.Y., Heisler, S., Axelrod, J. Proc. Natl. Acad. Sci. U.S.A. (1982)
- The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal. Contarino, A., Papaleo, F. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Contarino, A., Dellu, F., Koob, G.F., Smith, G.W., Lee, K.F., Vale, W., Gold, L.H. Brain Res. (1999)
- Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. Schmidt, M.V., Deussing, J.M., Oitzl, M.S., Ohl, F., Levine, S., Wurst, W., Holsboer, F., M??ller, M.B., de Kloet, E.R. Eur. J. Neurosci. (2006)
- Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919). Post, A., Ohl, F., Almeida, O.F., Binder, E.B., Rücker, M., Welt, S., Binder, E., Holsboer, F., Sillaber, I. Psychopharmacology (Berl.) (2005)
- Disruption of feeding behavior in CRH receptor 1-deficient mice is dependent on glucocorticoids. Müller, M.B., Keck, M.E., Zimmermann, S., Holsboer, F., Wurst, W. Neuroreport (2000)
- Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2. Kishimoto, T., Radulovic, J., Radulovic, M., Lin, C.R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M.G., Spiess, J. Nat. Genet. (2000)
- Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J.M., Stalla, G.K., Blanquet, V., Steckler, T., Holsboer, F., Wurst, W. Nat. Genet. (1998)
- Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Müller, M.B., Zimmermann, S., Sillaber, I., Hagemeyer, T.P., Deussing, J.M., Timpl, P., Kormann, M.S., Droste, S.K., Kühn, R., Reul, J.M., Holsboer, F., Wurst, W. Nat. Neurosci. (2003)
- Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775. Oshima, A., Flachskamm, C., Reul, J.M., Holsboer, F., Linthorst, A.C. Neuropsychopharmacology (2003)
- Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Bale, T.L., Contarino, A., Smith, G.W., Chan, R., Gold, L.H., Sawchenko, P.E., Koob, G.F., Vale, W.W., Lee, K.F. Nat. Genet. (2000)
- Distribution and expression of CRF receptor 1 and 2 mRNAs in the CRF over-expressing mouse brain. Korosi, A., Veening, J.G., Kozicz, T., Henckens, M., Dederen, J., Groenink, L., van der Gugten, J., Olivier, B., Roubos, E.W. Brain Res. (2006)
- Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Nie, Z., Schweitzer, P., Roberts, A.J., Madamba, S.G., Moore, S.D., Siggins, G.R. Science (2004)
- Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Refojo, D., Echenique, C., Müller, M.B., Reul, J.M., Deussing, J.M., Wurst, W., Sillaber, I., Paez-Pereda, M., Holsboer, F., Arzt, E. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids. Chen, A., Perrin, M., Brar, B., Li, C., Jamieson, P., Digruccio, M., Lewis, K., Vale, W. Mol. Endocrinol. (2005)
- Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids. Chen, A., Blount, A., Vaughan, J., Brar, B., Vale, W. Endocrinology (2004)
- Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. Schierloh, A., Deussing, J., Wurst, W., Zieglgänsberger, W., Rammes, G. Neurosci. Lett. (2007)
- CRF type I receptor-deficient mice exhibit a pronounced pituitary-adrenal response to local inflammation. Turnbull, A.V., Smith, G.W., Lee, S., Vale, W.W., Lee, K.F., Rivier, C. Endocrinology (1999)
- Localization of the type 1 corticotropin releasing factor receptor (CRF-R1) in the embryonic mouse cerebellum. King, J.S., Bishop, G.A. J. Neurocytol. (2003)
- Peptide specificity for stimulation of corticotropin secretion: activation of overlapping pathways by the vasoactive intestinal peptide family and corticotropin-releasing factor. Westendorf, J.M., Schonbrunn, A. Endocrinology (1985)
- IL-1alpha and TNFalpha down-regulate CRH receptor-2 mRNA expression in the mouse heart. Coste, S.C., Heldwein, K.A., Stevens, S.L., Tobar-Dupres, E., Stenzel-Poore, M.P. Endocrinology (2001)
- Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A.J., Sakurai, T., Kilduff, T.S., Horvath, T.L., de Lecea, L. J. Neurosci. (2004)
- Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. Müller, M.B., Landgraf, R., Preil, J., Sillaber, I., Kresse, A.E., Keck, M.E., Zimmermann, S., Holsboer, F., Wurst, W. Endocrinology (2000)
- Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei--potential implication for arousal and attention. Sauvage, M., Steckler, T. Neuroscience (2001)
- Corticotropin-releasing factor (CRF) agonists stimulate testosterone production in mouse leydig cells through CRF receptor-1. Heinrich, N., Meyer, M.R., Furkert, J., Sasse, A., Beyermann, M., Bönigk, W., Berger, H. Endocrinology (1998)
- Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. Radulovic, J., Rühmann, A., Liepold, T., Spiess, J. J. Neurosci. (1999)
- Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice. Contarino, A., Dellu, F., Koob, G.F., Smith, G.W., Lee, K.F., Vale, W.W., Gold, L.H. Endocrinology (2000)