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Gene Review:

HmgZ - HMG protein Z

Drosophila melanogaster

Synonyms: BcDNA:RE28596, CG17921, Dmel\CG17921, HMG-Z, High mobility group protein Z, ...

Ragab, A. et al., Wiśniewski, J.R. et al., Ner, S.S. et al.

Ragab, Thompson, Travers, Wiśniewski, Szewczuk, Petry, Schwanbeck, Renner,

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High impact information on HmgZ

Electrospray ionization mass spectroscopic analyses revealed that Drosophila HMGD and Chironomus HMG1a and HMG1b are double-phosphorylated and that Drosophila HMGZ is triple-phosphorylated [1].
High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila [2].

Biological context of HmgZ

The genes for dHMG-D and dHMG-Z are located on adjacent loci in the genome and each contains two introns [3].

Other interactions of HmgZ

To investigate their function genetically we have generated a defined deficiency uncovering the functionally redundant genes encoding HMGD and HMGZ, the Drosophila counterparts of HMGB1-3 in mammals [2].

References

Constitutive phosphorylation of the acidic tails of the high mobility group 1 proteins by casein kinase II alters their conformation, stability, and DNA binding specificity. Wiśniewski, J.R., Szewczuk, Z., Petry, I., Schwanbeck, R., Renner, U. J. Biol. Chem. (1999) [Pubmed]
High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila. Ragab, A., Thompson, E.C., Travers, A.A. Genetics (2006) [Pubmed]
dHMG-Z, a second HMG-1-related protein in Drosophila melanogaster. Ner, S.S., Churchill, M.E., Searles, M.A., Travers, A.A. Nucleic Acids Res. (1993) [Pubmed]

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AgaP_AGAP012334	Anopheles gambiae str. PEST
HmgD	Drosophila melanogaster

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