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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SBSN  -  suprabasin

Homo sapiens

Synonyms: HLAR698, Suprabasin, UNQ698, UNQ698/PRO1343
 
 
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High impact information on SBSN

  • The suprabasin gene is a novel gene expressed in mouse and human differentiating keratinocytes [1].
  • This region is syntenic to human chromosome band 19q13.1, which contained the only region in the data bases with homology to the mouse suprabasin sequence [1].
  • These findings indicated that dermokine-alpha/-beta, suprabasin, and Kdap are secreted from the spinous layer of the stratified epithelia and that these genes form a novel gene complex on the chromosome [2].
 

Associations of SBSN with chemical compounds

  • Differentiation of cultured primary epidermal keratinocytes with 0.12 mm Ca(2+) or 12-O-tetradecanoylphorbol-13-acetate treatment resulted in the induction of suprabasin [1].
 

Analytical, diagnostic and therapeutic context of SBSN

References

  1. Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor. Park, G.T., Lim, S.E., Jang, S.I., Morasso, M.I. J. Biol. Chem. (2002) [Pubmed]
  2. Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1. Matsui, T., Hayashi-Kisumi, F., Kinoshita, Y., Katahira, S., Morita, K., Miyachi, Y., Ono, Y., Imai, T., Tanigawa, Y., Komiya, T., Tsukita, S. Genomics (2004) [Pubmed]
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