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Gene Review

PFN4  -  profilin family, member 4

Homo sapiens

Synonyms: Profilin IV, Profilin-4
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High impact information on PFN4

  • Profilin IV thus may regulate testicular actin cytoskeleton dynamics and play a role in acrosome generation and spermatid nuclear shaping [1].
  • In the human testis, profilin IV mRNA expression correlates with the presence of germ cells suggesting that it may be a suitable molecular diagnostic parameter to supplement conventional histopathological diagnostics in the assessment of testicular biopsies [1].


  1. Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation. Obermann, H., Raabe, I., Balvers, M., Brunswig, B., Schulze, W., Kirchhoff, C. Mol. Hum. Reprod. (2005) [Pubmed]
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