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Gene Review

PTAR1  -  protein prenyltransferase alpha subunit...

Homo sapiens

Synonyms: Protein prenyltransferase alpha subunit repeat-containing protein 1
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Disease relevance of PTAR1

  • CONCLUSIONS: The presence of a PTAR did not adversely affect the outcome of thoracoabdominal aortic aneurysm repair [1].
  • Patients without PTAR were older, had more preoperative comorbid disease, and had more symptomatic or ruptured aneurysms [1].
  • BACKGROUND: The purpose of this study was to determine the impact of previous thoracic aortic aneurysm repair (PTAR) on subsequent thoracoabdominal aortic aneurysm operations [1].
  • Although differences did not reach statistical significance, patients without PTAR tended toward increased in-hospital mortality (8.5% versus 4.5%; p = 0.078) and postoperative paraplegia/paraparesis rates (6.5% versus 2.8%; p = 0.069) [1].

Analytical, diagnostic and therapeutic context of PTAR1

  • More patients without PTAR had cardiac complications (11.3% versus 5.6%; p = 0.028) and required chronic hemodialysis (5.9% versus 1.1%; p = 0.009) [1].
  • RESULTS: Patients with PTAR had more chronic dissections and extensive thoracoabdominal aortic aneurysms, and consequently required longer clamp and ischemic times and more intraoperative transfusions [1].


  1. Impact of previous thoracic aneurysm repair on thoracoabdominal aortic aneurysm management. Coselli, J.S., Poli de Figueiredo, L.F., LeMaire, S.A. Ann. Thorac. Surg. (1997) [Pubmed]
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