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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Paraparesis


Psychiatry related information on Paraparesis

  • Electromyographic reaction times (EMG-RTs) of the right knee extension were examined in eight normal subjects and eight patients with paraparesis under three conditions; during passive knee flexion (PFLX), passive extension (PEXT) and no passive movements (STAT) [6].
  • Clinical signs of disease included disorientation and truncal ataxia that rapidly progressed to hemiparesis or paraparesis [7].

High impact information on Paraparesis

  • Changes in the excitability of the soleus H-reflex are were studied after oral administration of L-acetylcarnitine, a cholinomimetic substance, in eight healthy control subjects and 23 spastic patients presenting with slowly progressive paraparesis (n = 10), a cord lesion (n = 9) and a cerebral lesion (n = 4) [8].
  • Ganciclovir therapy, 5-10 mg/kg per day, instituted 3-6.5 weeks after onset of symptoms, was ineffective in four patients with severe paraparesis [9].
  • Comparison of the mutation-positive group with the SPG4-excluded group revealed an older age at onset (p = 0.03), more disability (p = 0.001), more rapidly progressive paraparesis (p = 0.044), and more cognitive impairment (p = 0.024) among affected individuals with SPAST mutations, not confounded by disease duration [10].
  • Six of the eight (75%) WKA rats injected with MT-2 cells showed HAM/TSP-like paraparesis at 108 weeks of age [11].
  • After cyclophosphamide and glucocorticoid therapy, both her acute deficits and chronic paraparesis improved [12].

Chemical compound and disease context of Paraparesis


Anatomical context of Paraparesis


Gene context of Paraparesis


Analytical, diagnostic and therapeutic context of Paraparesis

  • Radiotherapy and bromocriptine in extreme doses (140 mg daily) together with an antiestrogen were not able to improve the neurological deficits (paraparesis) and to lower the PRL levels [28].


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  11. High incidence of HAM/TSP-like symptoms in WKA rats after administration of human T-cell leukemia virus type 1-producing cells. Kushida, S., Mizusawa, H., Matsumura, M., Tanaka, H., Ami, Y., Hori, M., Yagami, K., Kameyama, T., Tanaka, Y., Yoshida, A. J. Virol. (1994) [Pubmed]
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  13. The correlation between severity of paraparesis and reduced density of resident antigen-presenting cells implicates an unknown role for the spinal perivascular macrophages in experimental autoimmune encephalomyelitis in rats. Schmitz, D.N., Hofmann, N., Tomov, T.L., Kovac, A.D., Neiss, W.F., Angelov, D.N. J. Neuroimmunol. (2003) [Pubmed]
  14. Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: an experimental study in the rat using microdialysis. Farooque, M., Hillered, L., Holtz, A., Olsson, Y. J. Neurotrauma (1996) [Pubmed]
  15. Intrathecal papaverine for the prevention of paraplegia after operation on the thoracic or thoracoabdominal aorta. Svensson, L.G., Stewart, R.W., Cosgrove, D.M., Lytle, B.W., Antunes, M.D., Beven, E.G., Furlan, A.J., Gottlieb, A., Grum, D.F., Hinder, R.A. J. Thorac. Cardiovasc. Surg. (1988) [Pubmed]
  16. The effect of gamma-aminobutyric acid (GABA) receptor drugs on morphine-induced spastic paraparesis after a noninjurious interval of spinal cord ischemia in rats. Nakamura, S., Kakinohana, M., Taira, Y., Iha, H., Sugahara, K. Anesth. Analg. (2002) [Pubmed]
  17. Flaccid paraparesis following obstetrical epidural anesthesia: possible role of benzyl alcohol. Craig, D.B., Habib, G.G. Anesth. Analg. (1977) [Pubmed]
  18. Spontaneous murine neuroaxonal dystrophy: a model of infantile neuroaxonal dystrophy. Bouley, D.M., McIntire, J.J., Harris, B.T., Tolwani, R.J., Otto, G.M., Dekruyff, R.H., Hayflick, S.J. J. Comp. Pathol. (2006) [Pubmed]
  19. Efficacy of the 21-aminosteroid U74006F in improving neurological recovery after spinal cord injury in rats. Holtz, A., Gerdin, B. Neurol. Res. (1992) [Pubmed]
  20. Lower motor neuron disease in the Griffon Briquet Vendéen dog. Mandara, M.T., Di Meo, A. Vet. Pathol. (1998) [Pubmed]
  21. Hemiballismus revealing multiple sclerosis in an infant. Giroud, M., Semama, D., Pradeaux, L., Gouyon, J.B., Dumas, R., Nivelon, J.L. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1990) [Pubmed]
  22. Case report 384: Paraparesis from cauda equina compression due to disc herniation of L4-L5, in a patient with ossification of the posterior longitudinal ligament (OPLL) at L4-L5 and C4-C5. Merlini, L., Albisinni, U., Savini, R. Skeletal radiology. (1986) [Pubmed]
  23. The promiscuous IL-2/IL-15 receptor: a target for immunotherapy of HTLV-I-associated disorders. Waldmann, T.A. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. (1996) [Pubmed]
  24. Ossification of the posterior longitudinal ligament in the thoracic spine causing intermittent paraplegia in an Englishman: case report. Nakamura, H., Crock, H.V., Galbally, B.P., Dawson, J. Paraplegia. (1992) [Pubmed]
  25. Paraparesis in hereditary multiple exostoses: case report. Ferrari, G., Taddei, L., Vivenza, C., Rossi, G. Neurology (1979) [Pubmed]
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  27. Oculodentodigital dysplasia with cerebral white matter abnormalities in a two-generation family. Norton, K.K., Carey, J.C., Gutmann, D.H. Am. J. Med. Genet. (1995) [Pubmed]
  28. Hormone-active intradural spinal metastasis of a prolactinoma--a case report. Landgraf, R., Rieder, G., Schmiedek, P., Clados, D., Bise, K., von Werder, K. Klin. Wochenschr. (1985) [Pubmed]
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