Disease relevance of Aortic Aneurysm, Thoracic

• METHODS AND RESULTS: The FBN1 gene was screened for mutations by use of genomic DNA from two patients with thoracic aortic aneurysms who did not have the Marfan syndrome [1].
• CONCLUSION: Postoperative acute renal failure after thoracoabdominal and total descending thoracic aortic aneurysm surgery is associated with preoperative creatinine level, visceral perfusion, left renal artery reattachment, and simple cross-clamp technique [2].
• Sudden death caused by dissecting thoracic aortic aneurysm in a patient with autosomal dominant polycystic kidney disease [3].
• F-18 FDG PET imaging features of a perigraft leak and thrombus in a patient with dissecting descending thoracic aortic aneurysm [4].

High impact information on Aortic Aneurysm, Thoracic

• CONCLUSIONS: Results of these studies support the hypothesis that FBN1 mutations cause thoracic aortic aneurysms in patients who do not have the Marfan syndrome [1].
• Oxidative stress in the pathogenesis of thoracic aortic aneurysm: protective role of statin and angiotensin II type 1 receptor blocker [5].
• A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: a role for matrix metalloproteinase 9 and 2 [6].
• Systemic lupus erythematosus was suggested as possibly associated with nondissecting thoracic aortic aneurysm, especially in patients undergoing chronic steroid therapy in which inflammation continued [7].
• A 9-year-old girl with TS was diagnosed with a 3-cm calcified AAA, and a 41-year-old man with TS was diagnosed with a 7.5-cm thoracic aortic aneurysm (TAA) [8].

Chemical compound and disease context of Aortic Aneurysm, Thoracic

• Nitroglycerin to control blood pressure during endovascular stent-grafting of descending thoracic aortic aneurysms [9].
• In group 1, resection of descending thoracic aortic aneurysms (n = 24) was performed with heparin-coated equipment used for left heart bypass (n = 12) or partial cardiopulmonary bypass (n = 12) for proximal unloading and distal protection (heparin 5000 IU, autotransfusion) [10].
• Clinical application of a curved nitinol stent-graft for thoracic aortic aneurysms [11].
• Data on 230 patients with thoracic aortic aneurysms treated at Yale University School of Medicine from 1985 to 1996 were analyzed [12].
• We describe in three patients the use of adenosine to arrest the heart without cardiopulmonary bypass during endoluminal repair of thoracic aortic aneurysms [13].

Biological context of Aortic Aneurysm, Thoracic

• Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm [14].

Gene context of Aortic Aneurysm, Thoracic

• Recent studies suggest that abnormal matrix metalloproteinase activity may also be associated with the formation of atherosclerotic and nonatherosclerotic thoracic aortic aneurysms [15].
• Fibrillin-1 (FBN1) mutations in patients with thoracic aortic aneurysms [1].
• Posttraumatic thoracic aortic aneurysm associated with a diaphragmatic hernia [16].
• Successful resection of thoracic aortic aneurysms in Wiskott-Aldrich syndrome [17].
• To analyze the effectiveness of thoracoabdominal and descending thoracic aortic aneurysm repair, we computed the NNT required to prevent one death [18].

Analytical, diagnostic and therapeutic context of Aortic Aneurysm, Thoracic

• We tested the hypothesis that FBN1 mutations cause thoracic aortic aneurysms or dissections in patients who do not have the Marfan syndrome [1].
• We also measured concentrations of the soluble VCAM-1 using two-site enzyme immunoassays in 40 healthy volunteers and in 13 patients with abdominal and thoracic aortic aneurysms [19].
• Within 6 months, he redeveloped a thoracic aortic aneurysm, necessitating reoperation and lifelong parenteral antibiotic therapy [20].

References