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MeSH Review

Aortic Aneurysm

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Disease relevance of Aortic Aneurysm


High impact information on Aortic Aneurysm


Chemical compound and disease context of Aortic Aneurysm


Biological context of Aortic Aneurysm


Anatomical context of Aortic Aneurysm

  • Thoracoabdominal aortic aneurysms associated with celiac, superior mesenteric, and renal artery occlusive disease: methods and analysis of results in 271 patients [18].
  • This study evaluated the effect of cerebrospinal fluid (CSF) drainage, with and without distal femoral perfusion or moderate hypothermia on blood and CSF lactate concentrations and CSF pressure during thoracoabdominal aortic aneurysm surgery [19].
  • Thirteen patients (mean age, 75 years) were selected between January 1980 and June 1984 for axillobifemoral bypass with bilateral iliac artery occlusion to manage their infrarenal aortic aneurysms (mean size, 6.3 cm; range, 4.9 to 7.5 cm) [20].
  • CONCLUSIONS: Totally percutaneous aortic aneurysm repair is technically feasible in most cases, with no effect on the luminal diameter of the accessed femoral artery [21].
  • Of the four major coronary arteries, the average number of severely narrowed arteries (reduction of more than 75 per cent) in cross-sectional luminal area) was 1.8/patient; aortic aneurysms were present in eight of these patients (24 per cent) [22].

Gene context of Aortic Aneurysm

  • A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms [23].
  • Spontaneous aortic aneurysms in blotchy mice [24].
  • This study investigated the production of the MMP-2-MT1-MMP-tissue inhibitor of metalloproteinases (TIMP) 2 system within the wall of aortic aneurysms and in age-matched control arterial tissue [25].
  • OBJECTIVES: Plasma proinflammatory, anti-inflammatory cytokine, and soluble tumor necrosis factor (TNF) receptor concentrations were examined in hospitalized patients after abdominal and thoracoabdominal aortic aneurysm (TAAA) repair, with and without left atrial femoral bypass [26].
  • CONCLUSION: The high concentration of MMP-8 in aortic aneurysms represents a potent pathway for collagen degradation, and hence aneurysm formation and expansion [27].

Analytical, diagnostic and therapeutic context of Aortic Aneurysm


  1. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. Pyo, R., Lee, J.K., Shipley, J.M., Curci, J.A., Mao, D., Ziporin, S.J., Ennis, T.L., Shapiro, S.D., Senior, R.M., Thompson, R.W. J. Clin. Invest. (2000) [Pubmed]
  2. Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context? Curci, J.A., Thompson, R.W. J. Clin. Invest. (2004) [Pubmed]
  3. Inheritance of an RNA splicing mutation (G+ 1 IVS20) in the type III procollagen gene (COL3A1) in a family having aortic aneurysms and easy bruisability: phenotypic overlap between familial arterial aneurysms and Ehlers-Danlos syndrome type IV. Kontusaari, S., Tromp, G., Kuivaniemi, H., Ladda, R.L., Prockop, D.J. Am. J. Hum. Genet. (1990) [Pubmed]
  4. Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Pereira, L., Lee, S.Y., Gayraud, B., Andrikopoulos, K., Shapiro, S.D., Bunton, T., Biery, N.J., Dietz, H.C., Sakai, L.Y., Ramirez, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Abdominal aortic aneurysms and autosomal dominant polycystic kidney disease. Torra, R., Nicolau, C., Badenas, C., Brú, C., Pérez, L., Estivill, X., Darnell, A. J. Am. Soc. Nephrol. (1996) [Pubmed]
  6. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Zhao, L., Moos, M.P., Gräbner, R., Pédrono, F., Fan, J., Kaiser, B., John, N., Schmidt, S., Spanbroek, R., Lötzer, K., Huang, L., Cui, J., Rader, D.J., Evans, J.F., Habenicht, A.J., Funk, C.D. Nat. Med. (2004) [Pubmed]
  7. Superior vena cava obstruction and dissecting aortic aneurysm. Spitzer, S., Blanco, G., Adam, A., Spyrou, P.G., Mason, D. JAMA (1975) [Pubmed]
  8. Angiotensin II, atherosclerosis, and aortic aneurysms. Berk, B.C., Haendeler, J., Sottile, J. J. Clin. Invest. (2000) [Pubmed]
  9. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. Curci, J.A., Liao, S., Huffman, M.D., Shapiro, S.D., Thompson, R.W. J. Clin. Invest. (1998) [Pubmed]
  10. Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. Allaire, E., Forough, R., Clowes, M., Starcher, B., Clowes, A.W. J. Clin. Invest. (1998) [Pubmed]
  11. Use of nitroprusside during surgery for thoracoabdominal aortic aneurysm. Shenaq, S.A., Chelly, J.E., Karlberg, H., Cohen, E., Crawford, E.S. Circulation (1984) [Pubmed]
  12. Light- and electron-microscopic observations of theophylline-induced aortic aneurysms in embryonic chicks. Yokoyama, H., Matsuoka, R., Bruyere, H.J., Gilbert, E.F., Uno, H. Am. J. Pathol. (1983) [Pubmed]
  13. Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. Xu, Q., Ji, Y.S., Schmedtje, J.F. J. Biol. Chem. (2000) [Pubmed]
  14. Regulation of lysyl oxidase by interferon-gamma in rat aortic smooth muscle cells. Song, Y.L., Ford, J.W., Gordon, D., Shanley, C.J. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  15. Salt-sensitive aortic aneurysm and rupture in hypertensive transgenic mice that overproduce angiotensin II. Nishijo, N., Sugiyama, F., Kimoto, K., Taniguchi, K., Murakami, K., Suzuki, S., Fukamizu, A., Yagami, K. Lab. Invest. (1998) [Pubmed]
  16. The relationship between evoked potentials and measurements of S-100 protein in cerebrospinal fluid during and after thoracoabdominal aortic aneurysm surgery. van Dongen, E.P., ter Beek, H.T., Schepens, M.A., Morshuis, W.J., Haas, F.J., de Boer, A., Boezeman, E.H., Aarts, L.P. J. Vasc. Surg. (1999) [Pubmed]
  17. Kinetics and fate of indium 111 oxine-labeled platelets in patients with aortic aneurysms. Heyns, A.D., Lötter, M.G., Badenhorst, P.N., Pieters, H., Nel, C.J., Minnaar, P.C. Archives of surgery (Chicago, Ill. : 1960) (1982) [Pubmed]
  18. Thoracoabdominal aortic aneurysms associated with celiac, superior mesenteric, and renal artery occlusive disease: methods and analysis of results in 271 patients. Svensson, L.G., Crawford, E.S., Hess, K.R., Coselli, J.S., Safi, H.J. J. Vasc. Surg. (1992) [Pubmed]
  19. Changes in cerebrospinal fluid pressure and lactate concentrations during thoracoabdominal aortic aneurysm surgery. Drenger, B., Parker, S.D., Frank, S.M., Beattie, C. Anesthesiology (1997) [Pubmed]
  20. Is thrombosis of the infrarenal abdominal aortic aneurysm an acceptable alternative? Schwartz, R.A., Nichols, W.K., Silver, D. J. Vasc. Surg. (1986) [Pubmed]
  21. Totally percutaneous aortic aneurysm repair: experience and prudence. Starnes, B.W., Andersen, C.A., Ronsivalle, J.A., Stockmaster, N.R., Mullenix, P.S., Statler, J.D. J. Vasc. Surg. (2006) [Pubmed]
  22. Acquired coronary arterial aneurysms: an autopsy study of 52 patients. Virmani, R., Robinowitz, M., Atkinson, J.B., Forman, M.B., Silver, M.D., McAllister, H.A. Hum. Pathol. (1986) [Pubmed]
  23. A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms. Kontusaari, S., Tromp, G., Kuivaniemi, H., Romanic, A.M., Prockop, D.J. J. Clin. Invest. (1990) [Pubmed]
  24. Spontaneous aortic aneurysms in blotchy mice. Andrews, E.J., White, W.J., Bullock, L.P. Am. J. Pathol. (1975) [Pubmed]
  25. Localization of matrix metalloproteinase 2 within the aneurysmal and normal aortic wall. Crowther, M., Goodall, S., Jones, J.L., Bell, P.R., Thompson, M.M. The British journal of surgery. (2000) [Pubmed]
  26. The relationship between visceral ischemia, proinflammatory cytokines, and organ injury in patients undergoing thoracoabdominal aortic aneurysm repair. Welborn, M.B., Oldenburg, H.S., Hess, P.J., Huber, T.S., Martin, T.D., Rauwerda, J.A., Wesdorp, R.I., Espat, N.J., Copeland, E.M., Moldawer, L.L., Seeger, J.M. Crit. Care Med. (2000) [Pubmed]
  27. Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm. Wilson, W.R., Schwalbe, E.C., Jones, J.L., Bell, P.R., Thompson, M.M. The British journal of surgery. (2005) [Pubmed]
  28. Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. Modur, V., Feldhaus, M.J., Weyrich, A.S., Jicha, D.L., Prescott, S.M., Zimmerman, G.A., McIntyre, T.M. J. Clin. Invest. (1997) [Pubmed]
  29. Molecular cloning of genes differentially regulated by TNF-alpha in bovine aortic endothelial cells, fibroblasts and smooth muscle cells. Lin, J., Liliensiek, B., Kanitz, M., Schimanski, U., Böhrer, H., Waldherr, R., Martin, E., Kauffmann, G., Ziegler, R., Nawroth, P.P. Cardiovasc. Res. (1998) [Pubmed]
  30. Randomized controlled trial of the effect of mannitol on renal reperfusion injury during aortic aneurysm surgery. Tisi, P.V., Shearman, C.P. The British journal of surgery. (1997) [Pubmed]
  31. Acute acalculous cholecystitis complicating abdominal aortic aneurysm resection. Ouriel, K., Green, R.M., Ricotta, J.J., DeWeese, J.A., Adams, J.T. J. Vasc. Surg. (1984) [Pubmed]
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