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Gene Review

dnr1  -  defense repressor 1

Drosophila melanogaster

Synonyms: CG12489, DNR1, Dmel\CG12489, Dnr1
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High impact information on Dnr1

  • Conversely, we demonstrate that overexpression of Dnr1 blocks apoptotic caspase activity and prevents induction of apoptosis in tissue culture assays [1].
  • In this study, we present novel data indicating that Dnr1 impacts on Dronc-dependent regulation of the apoptotic program [1].
  • The RING-domain-bearing protein Defense repressor 1 (Dnr1), blocks ectopic Dredd-mediated induction of an NF-kappaB reporter in the Drosophila S2 cell line [1].

Regulatory relationships of Dnr1


Other interactions of Dnr1

  • We also showed that a second gene, defense repressor 1, encodes a product with characteristics of an inhibitor of apoptosis protein that inhibits the Dredd caspase to maintain quiescence of the signaling pathway [2].


  1. Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster. Primrose, D.A., Chaudhry, S., Johnson, A.G., Hrdlicka, A., Schindler, A., Tran, D., Foley, E. J. Cell. Sci. (2007) [Pubmed]
  2. Functional dissection of an innate immune response by a genome-wide RNAi screen. Foley, E., O'Farrell, P.H. PLoS Biol. (2004) [Pubmed]
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