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Gene Review

Dredd  -  Death related ced-3/Nedd2-like protein

Drosophila melanogaster

Synonyms: CASP8_DROME, CG7486, Caspase-8, DCP-2, DCP-2/DREDD, ...
 
 
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Disease relevance of Dredd

 

High impact information on Dredd

  • Dark-induced cell killing is suppressed by caspase-inhibitory peptides and by a dominant-negative mutant Dredd protein, and enhanced by removal of the WD domain [3].
  • We found that Kep1 bound dredd RNA in vitro, and that extracts prepared from kep1 mutant ovaries had markedly reduced proteolytic cleavage activity toward the caspase-8 target substrate IETD-7-amino-4-trifluoromethyl coumarin [4].
  • Epistatic studies indicate that dFADD acts between Imd and Dredd [5].
  • Unlike its mammalian counterparts, however, the apoptotic effect of Eiger does not require the activity of the caspase-8 homolog DREDD, but it completely depends on its ability to activate the JNK pathway [6].
  • The RING-domain-bearing protein Defense repressor 1 (Dnr1), blocks ectopic Dredd-mediated induction of an NF-kappaB reporter in the Drosophila S2 cell line [2].
 

Biological context of Dredd

  • Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila [7].
 

Regulatory relationships of Dredd

 

Other interactions of Dredd

  • We also showed that a second gene, defense repressor 1, encodes a product with characteristics of an inhibitor of apoptosis protein that inhibits the Dredd caspase to maintain quiescence of the signaling pathway [1].
  • We observed increased levels of the beta isoform of dredd mRNA in kep1 mutants as compared with wild-type [4].

References

  1. Functional dissection of an innate immune response by a genome-wide RNAi screen. Foley, E., O'Farrell, P.H. PLoS Biol. (2004) [Pubmed]
  2. Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster. Primrose, D.A., Chaudhry, S., Johnson, A.G., Hrdlicka, A., Schindler, A., Tran, D., Foley, E. J. Cell. Sci. (2007) [Pubmed]
  3. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Rodriguez, A., Oliver, H., Zou, H., Chen, P., Wang, X., Abrams, J.M. Nat. Cell Biol. (1999) [Pubmed]
  4. Kep1 interacts genetically with dredd/caspase-8, and kep1 mutants alter the balance of dredd isoforms. Di Fruscio, M., Styhler, S., Wikholm, E., Boulanger, M.C., Lasko, P., Richard, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Leulier, F., Vidal, S., Saigo, K., Ueda, R., Lemaitre, B. Curr. Biol. (2002) [Pubmed]
  6. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Moreno, E., Yan, M., Basler, K. Curr. Biol. (2002) [Pubmed]
  7. Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Chen, P., Rodriguez, A., Erskine, R., Thach, T., Abrams, J.M. Dev. Biol. (1998) [Pubmed]
 
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