Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Dredd - Death related ced-3/Nedd2-like protein

Drosophila melanogaster

Synonyms: CASP8_DROME, CG7486, Caspase-8, DCP-2, DCP-2/DREDD, ...

Foley, E. et al., Di Fruscio, M. et al., Primrose, D.A. et al., Moreno, E. et al., Rodriguez, A. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dredd

Activation of the NF-kappaB family member Relish by the caspase-8 homolog Dredd is a central, but still poorly understood, signaling module in the response to gram-negative bacteria [1].
In Drosophila, the caspase-9 counterpart Dronc is essential for most apoptotic death, whereas the caspase-8 homolog Dredd activates NF-kappaB signaling in response to gram-negative bacterial infection [2].

High impact information on Dredd

Dark-induced cell killing is suppressed by caspase-inhibitory peptides and by a dominant-negative mutant Dredd protein, and enhanced by removal of the WD domain [3].
We found that Kep1 bound dredd RNA in vitro, and that extracts prepared from kep1 mutant ovaries had markedly reduced proteolytic cleavage activity toward the caspase-8 target substrate IETD-7-amino-4-trifluoromethyl coumarin [4].
Epistatic studies indicate that dFADD acts between Imd and Dredd [5].
Unlike its mammalian counterparts, however, the apoptotic effect of Eiger does not require the activity of the caspase-8 homolog DREDD, but it completely depends on its ability to activate the JNK pathway [6].
The RING-domain-bearing protein Defense repressor 1 (Dnr1), blocks ectopic Dredd-mediated induction of an NF-kappaB reporter in the Drosophila S2 cell line [2].

Biological context of Dredd

Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila [7].

Regulatory relationships of Dredd

Molecular analysis revealed that Defense repressor 1 is upregulated by Dredd in a feedback loop [1].
Taken together, our results suggest that Kep1 regulates apoptosis by influencing the processing of dredd RNA [4].

Other interactions of Dredd

We also showed that a second gene, defense repressor 1, encodes a product with characteristics of an inhibitor of apoptosis protein that inhibits the Dredd caspase to maintain quiescence of the signaling pathway [1].
We observed increased levels of the beta isoform of dredd mRNA in kep1 mutants as compared with wild-type [4].

References

Functional dissection of an innate immune response by a genome-wide RNAi screen. Foley, E., O'Farrell, P.H. PLoS Biol. (2004) [Pubmed]
Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster. Primrose, D.A., Chaudhry, S., Johnson, A.G., Hrdlicka, A., Schindler, A., Tran, D., Foley, E. J. Cell. Sci. (2007) [Pubmed]
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Rodriguez, A., Oliver, H., Zou, H., Chen, P., Wang, X., Abrams, J.M. Nat. Cell Biol. (1999) [Pubmed]
Kep1 interacts genetically with dredd/caspase-8, and kep1 mutants alter the balance of dredd isoforms. Di Fruscio, M., Styhler, S., Wikholm, E., Boulanger, M.C., Lasko, P., Richard, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Leulier, F., Vidal, S., Saigo, K., Ueda, R., Lemaitre, B. Curr. Biol. (2002) [Pubmed]
Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Moreno, E., Yan, M., Basler, K. Curr. Biol. (2002) [Pubmed]
Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Chen, P., Rodriguez, A., Erskine, R., Thach, T., Abrams, J.M. Dev. Biol. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.