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MYLIP  -  myosin regulatory light chain interacting...

Homo sapiens

Synonyms: BM-023, BZF1, E3 ubiquitin-protein ligase MYLIP, IDOL, Idol, ...
 
 
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Disease relevance of MYLIP

  • Urinary albumin, as index of proteinuria, was analyzed in frozen urine samples collected by astronauts during space missions onboard MIR station and on ground (control) [1].
  • The aim of present investigations was to study dynamic changes of hormone levels during the stress and metabolic loads (insulin induced hypoglycemia, physical exercise and oral glucose tolerance test) at the exposure of human subject to microgravity on the space station MIR [2].
 

Psychiatry related information on MYLIP

  • A search using the gene bank showed that the MIR gene localised to human chromosome 6 in the interval 6p22.3-23, the loss of which is characterized by mental retardation and different malformations in man [3].
  • We measured nonspecific (attention, mental flexibility, psychomotor speed) and visuospatial cognitive processing in a single case study during a 6-d visit on the Russian orbital complex MIR, using computer-based psychometric tasks [4].
 

High impact information on MYLIP

 

Biological context of MYLIP

  • Cell fractionation revealed a similar distribution of full-length MIR and the RING domain protein in the Triton X-100-insoluble fraction [7].
  • MIR contains, beside the ERM domain, a RING zinc finger region [7].
  • RESULTS: SIR youth had higher visceral adiposity (78.3 +/- 6.9 vs. 60.3 +/- 6.9 cm(2), P = 0.017) and waist-to-hip ratio (0.91 +/- 0.01 vs. 0.86 +/- 0.02, P = 0.026) and lower HDL (1.0 +/- 0.03 vs. 1.16 +/- 0.06 mmol/l, P = 0.015) than pair-matched MIR subjects [8].
  • MIR elements, whose total number in the genome was estimated to be about 3.3 x 10(5), were found to be unevenly distributed in human isochores [9].
  • The bone mineral density and the biochemical parameters exploring bone cell activities were analyzed in two cosmonauts who spent 1 and 6 months, respectively, in the Russian MIR station [10].
 

Anatomical context of MYLIP

  • Here we describe a novel protein MSAP (MIR-interacting saposin-like protein) that is a positive regulator of neurite outgrowth [5].
  • In the yeast two-hybrid system and in transfected COS cells, MIR interacts with myosin regulatory light chain B, which in turn regulates the activity of the actomyosin complex [6].
  • Immunohistochemistry and double labelling studies showed that MIR is localized especially to neurons in hippocampus and cerebellum [3].
  • The presence of MIR in brain neurons during development together with its known effects on neurite outgrowth suggest an important function of the protein in the regulation of nerve cell motility and cytoskeletal interactions [3].
  • The maximal explosive power of the lower limbs of one astronaut has been measured before launch, and 2, 6 and 11 days after re-entry from 31 days on the MIR Station (EUROMIR '94) [11].
 

Associations of MYLIP with chemical compounds

  • The fast relaxation dynamics of 1,6-dihydro-2-methyl-6-oxo-3,4'-bipyridine-5-carbonitrile (milrinone, MIR), a cardiotonic drug, has been characterized in water solutions at different pH [12].
  • We measured the urinary excretion of the F(2) isoprostane, 8-iso-prostaglandin (PG) F(2alpha), and 8-oxo-7,8-dihydro-2 deoxyguanosine (8-OH DG) before, during, and after long-duration spaceflight (4-9 mo) on the Russian space station MIR, short-duration spaceflight on the shuttle, and 17 days of bed rest [13].
  • Most astronauts on Apollo, Skylab, and MIR reported 'flashes of light' occurring in different shapes and apparently moving across the visual field, in the absence of auditory, somatosensory, or olfactory abnormal percepts [14].
  • The use of this detector permits a registration of the LET spectrum of charged particles within wide range of dE/dx and during the last years it has already been successfully used on board the MIR station, Space Shuttles and "Kosmos" spacecrafts [15].
  • Here we investigate the utility of ATR-MIR to monitor and predict concentrations of glycerol and product (clavulanic acid) in a complex antibiotic bioprocess [16].
 

Analytical, diagnostic and therapeutic context of MYLIP

  • Immunocytochemistry showed that full-length MIR and the subdomains localize differently in cells [7].
  • As shown using Western blotting, MIR is present in different regions both in developing and adult brain [3].
  • The combination of near- and midinfrared spectroscopies (NIR and MIR) is proposed to monitor temperature-dependent transitions of proteins [17].
  • For this reason, the assessment of MIR distribution by inter-repeat PCR led to an overestimation of MIR numbers in H2 isochore and an underestimation in L isochores [9].
  • Office spirometry was performed by GPs who were trained by reference specialists using a portable electronic spirometer (Spirobank Office; MIR; Rome, Italy) [18].

References

  1. Urinary albumin in space missions. Cirillo, M., De Santo, N.G., Heer, M., Norsk, P., Elmann-Larsen, B., Bellini, L., Stellato, D., Drummer, C. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (2002) [Pubmed]
  2. Plasma hormone levels in human subject during stress loads in microgravity and at readaptation to Earth's gravity. Macho, L., Koska, J., Ksinantova, L., Vigas, M., Noskov, V.B., Grigoriev, A.I., Kvetnansky, R. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (2001) [Pubmed]
  3. Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6. Olsson, P.A., Bornhauser, B.C., Korhonen, L., Lindholm, D. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  4. Space and cognition: the measurement of behavioral functions during a 6-day space mission. Benke, T., Koserenko, O., Watson, N.V., Gerstenbrand, F. Aviation, space, and environmental medicine. (1993) [Pubmed]
  5. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. Bornhauser, B.C., Olsson, P.A., Lindholm, D. J. Biol. Chem. (2003) [Pubmed]
  6. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. Olsson, P.A., Korhonen, L., Mercer, E.A., Lindholm, D. J. Biol. Chem. (1999) [Pubmed]
  7. Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. Bornhauser, B.C., Johansson, C., Lindholm, D. FEBS Lett. (2003) [Pubmed]
  8. Are obesity-related metabolic risk factors modulated by the degree of insulin resistance in adolescents? Bacha, F., Saad, R., Gungor, N., Arslanian, S.A. Diabetes Care (2006) [Pubmed]
  9. Distribution of the mammalian-wide interspersed repeats (MIRs) in the isochores of the human genome. Matassi, G., Labuda, D., Bernardi, G. FEBS Lett. (1998) [Pubmed]
  10. Effects of 1- and 6-month spaceflight on bone mass and biochemistry in two humans. Collet, P., Uebelhart, D., Vico, L., Moro, L., Hartmann, D., Roth, M., Alexandre, C. Bone (1997) [Pubmed]
  11. Effects of microgravity on muscular explosive power of the lower limbs in humans. Antonutto, G., Capelli, C., Giradis, M., Zamparo, P., di Prampero, P.E. Acta astronautica. (1995) [Pubmed]
  12. Fast relaxation dynamics of the cardiotonic drug milrinone in water solutions. el-Kemary, M., Organero, J.A., Douhal, A. J. Med. Chem. (2006) [Pubmed]
  13. Oxidant damage during and after spaceflight. Stein, T.P., Leskiw, M.J. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  14. Positive visual phenomena in space: A scientific case and a safety issue in space travel. Sannita, W.G., Narici, L., Picozza, P. Vision Res. (2006) [Pubmed]
  15. Radiation measurement on the International Space Station. Akopova, A.B., Manaseryan, M.M., Melkonyan, A.A., Tatikyan, S.S.h., Potapov, Y. Radiation measurements. (2005) [Pubmed]
  16. Simultaneous determination of glycerol and clavulanic acid in an antibiotic bioprocess using attenuated total reflectance mid infrared spectroscopy. Roychoudhury, P., McNeil, B., Harvey, L.M. Anal. Chim. Acta (2007) [Pubmed]
  17. Modeling temperature-dependent protein structural transitions by combined near-IR and mid-IR spectroscopies and multivariate curve resolution. Navea, S., de Juan, A., Tauler, R. Anal. Chem. (2003) [Pubmed]
  18. A randomized controlled trial on office spirometry in asthma and COPD in standard general practice: data from spirometry in Asthma and COPD: a comparative evaluation Italian study. Lusuardi, M., De Benedetto, F., Paggiaro, P., Sanguinetti, C.M., Brazzola, G., Ferri, P., Donner, C.F. Chest (2006) [Pubmed]
 
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