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Gene Review

Ext2  -  CG8433 gene product from transcript CG8433-RB

Drosophila melanogaster

Synonyms: BcDNA:GH02288, CG33038, CG8433, DEXT2, DExt2, ...
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High impact information on Ext2

  • We have identified and isolated the other two members of the Drosophila EXT family genes, which are named sister of tout-velu (sotv) and brother of tout-velu (botv), and encode Drosophila homologues of vertebrate EXT2 and EXT-like 3 (EXTL3), respectively [1].
  • Here we demonstrated that TTV/DEXT1 and SOTV/DEXT2 had GlcNAcT-II and GlcAT-II activities required for the biosynthesis of repeating disaccharide units of the HS backbone, and the coexpression of TTV with SOTV markedly augmented both glycosyltransferase activities when compared with the expression of TTV or SOTV alone [2].


  1. Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Han, C., Belenkaya, T.Y., Khodoun, M., Tauchi, M., Lin, X., Lin, X. Development (2004) [Pubmed]
  2. Heparan sulfate polymerization in Drosophila. Izumikawa, T., Egusa, N., Taniguchi, F., Sugahara, K., Kitagawa, H. J. Biol. Chem. (2006) [Pubmed]
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