The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Ext2  -  exostoses (multiple) 2

Mus musculus

Synonyms: AI893565, Exostosin-2, Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostoses protein 2 homolog
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Ext2

 

High impact information on Ext2

  • The importance of proteoglycans for proliferation increases during development in parallel with increasing expression of the glycosyltransferase genes, exostosin 1 and exostosin 2 [2].
 

Analytical, diagnostic and therapeutic context of Ext2

  • To study the relationship of the disease to mutations in these genes, we generated Ext2-null mice by gene targeting [1].

References

  1. Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Stickens, D., Zak, B.M., Rougier, N., Esko, J.D., Werb, Z. Development (2005) [Pubmed]
  2. Cerebellar proteoglycans regulate sonic hedgehog responses during development. Rubin, J.B., Choi, Y., Segal, R.A. Development (2002) [Pubmed]
 
WikiGenes - Universities