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Gene Review

Ext2  -  exostoses (multiple) 2

Mus musculus

Synonyms: AI893565, Exostosin-2, Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostoses protein 2 homolog
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Disease relevance of Ext2


High impact information on Ext2

  • The importance of proteoglycans for proliferation increases during development in parallel with increasing expression of the glycosyltransferase genes, exostosin 1 and exostosin 2 [2].

Analytical, diagnostic and therapeutic context of Ext2

  • To study the relationship of the disease to mutations in these genes, we generated Ext2-null mice by gene targeting [1].


  1. Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Stickens, D., Zak, B.M., Rougier, N., Esko, J.D., Werb, Z. Development (2005) [Pubmed]
  2. Cerebellar proteoglycans regulate sonic hedgehog responses during development. Rubin, J.B., Choi, Y., Segal, R.A. Development (2002) [Pubmed]
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