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Gene Review

ttv  -  tout-velu

Drosophila melanogaster

Synonyms: CG10117, DEXT1, Dmel\CG10117, Exostosin-1, Ext1, ...
 
 
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Disease relevance of ttv

 

High impact information on ttv

  • Here we identify a new Drosophila gene, named tout-velu, that is required for diffusion of Hedgehog [2].
  • We have previously identified tout velu (ttv), a homolog of the mammalian EXT tumor suppressor gene family, as a gene required for movement of Hh [3].
  • In contrast to mutants in other HSPG biosynthesis genes, the activity of the HSPG-dependent FGF and Wingless signaling pathways are not affected in ttv mutants [3].
  • Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan [3].
  • Here we demonstrated that TTV/DEXT1 and SOTV/DEXT2 had GlcNAcT-II and GlcAT-II activities required for the biosynthesis of repeating disaccharide units of the HS backbone, and the coexpression of TTV with SOTV markedly augmented both glycosyltransferase activities when compared with the expression of TTV or SOTV alone [4].
 

Biological context of ttv

 

Other interactions of ttv

  • These findings show that sugarless, sulfateless, and tout-velu affect glycosaminoglycan biosynthesis and demonstrate the utility of Drosophila as a model organism for studying the function and biosynthesis of glycosaminoglycans in vivo [1].
  • Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes [1].

References

  1. Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes. Toyoda, H., Kinoshita-Toyoda, A., Fox, B., Selleck, S.B. J. Biol. Chem. (2000) [Pubmed]
  2. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Bellaiche, Y., The, I., Perrimon, N. Nature (1998) [Pubmed]
  3. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. The, I., Bellaiche, Y., Perrimon, N. Mol. Cell (1999) [Pubmed]
  4. Heparan sulfate polymerization in Drosophila. Izumikawa, T., Egusa, N., Taniguchi, F., Sugahara, K., Kitagawa, H. J. Biol. Chem. (2006) [Pubmed]
  5. Molecular genetic analysis of the nested Drosophila melanogaster lamin C gene. Schulze, S.R., Curio-Penny, B., Li, Y., Imani, R.A., Rydberg, L., Geyer, P.K., Wallrath, L.L. Genetics (2005) [Pubmed]
  6. Structural analysis of glycosaminoglycans in Drosophila and Caenorhabditis elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivo. Toyoda, H., Kinoshita-Toyoda, A., Selleck, S.B. J. Biol. Chem. (2000) [Pubmed]
  7. Transgenic expression of the EXT2 gene in developing chondrocytes enhances the synthesis of heparan sulfate and bone formation in mice. Morimoto, K., Shimizu, T., Furukawa, K., Morio, H., Kurosawa, H., Shirasawa, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
 
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