Gene Review:
seq - sequoia
Drosophila melanogaster
Synonyms:
2R5, 49Fc, CG17724b, CG32904, CG4037, ...
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High impact information on seq
- We identified the sequoia mutant from a previous screen for dendrite mutants [1].
- Here we report that Sequoia is a pan-neural nuclear protein containing two putative zinc fingers homologous to the DNA binding domain of Tramtrack. sequoia mutants affect the cell fate decision of a small subset of neurons but have global effects on axon and dendrite morphologies of most and possibly all neurons [1].
- In support of sequoia as a specific regulator of neuronal morphogenesis, microarray experiments indicate that sequoia may regulate downstream genes that are important for executing neurite development rather than altering a variety of molecules that specify cell fates [1].
Biological context of seq
- Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila [1].
References
- Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila. Brenman, J.E., Gao, F.B., Jan, L.Y., Jan, Y.N. Dev. Cell (2001) [Pubmed]
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