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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CG4049  -  CG4049 gene product from transcript CG4049-RA

Drosophila melanogaster

Synonyms: Arip4, BEST:LD04705, Dmel\CG4049
 
 
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High impact information on CG4049

  • Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, and members of the pro-inflammatory interleukin-1 receptor (IL-1R) family, share homologies in their cytoplasmic domains called Toll/IL-1R/plant R gene homology (TIR) domains [1].
  • EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases [2].
  • This R gene subclass encodes a combined nucleotide-binding domain/leucine rich region (NBD/LRR) motif [3].

References

  1. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Suzuki, N., Suzuki, S., Duncan, G.S., Millar, D.G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A., Itie, A., Li, S., Penninger, J.M., Wesche, H., Ohashi, P.S., Mak, T.W., Yeh, W.C. Nature (2002) [Pubmed]
  2. EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Falk, A., Feys, B.J., Frost, L.N., Jones, J.D., Daniels, M.J., Parker, J.E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. The CATERPILLER family: an ancient family of immune/apoptotic proteins. Ting, J.P., Williams, K.L. Clin. Immunol. (2005) [Pubmed]
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