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Gene Review:

BAB1_1488 - choloylglycine hydrolase

Brucella melitensis biovar Abortus 2308

Delpino, M.V. et al.

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Disease relevance of BAB1_1488

This study shows that CGH confers on Brucella the ability to resist the antimicrobial action of bile salts [1].

High impact information on BAB1_1488

We obtained the Brucella CGH in recombinant form and demonstrated in vitro its capacity to cleave glycocholate into glycine and cholate [1].
Choloylglycine hydrolase (CGH), a bile salt hydrolase, has been annotated in all the available genomes of Brucella species [1].

References

A Bile Salt Hydrolase of Brucella abortus Contributes to the Establishment of a Successful Infection through the Oral Route in Mice. Delpino, M.V., Marchesini, M.I., Estein, S.M., Comerci, D.J., Cassataro, J., Fossati, C.A., Baldi, P.C. Infect. Immun. (2007) [Pubmed]

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