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Gene Review:

SAB0424 - alpha-glucosidase

Staphylococcus aureus RF122

Karasuno, T. et al., Tanaka, M. et al., Pessione, E. et al.

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Disease relevance of SAB0424

Alteration of membrane oligosaccharides by castanospermine, an alpha glucosidase inhibitor, enhances immunoglobulin production in Staphylococcus aureus Cowan I-stimulated lymphocyte culture [1].

High impact information on SAB0424

Although a single addition of ascorbate was without effect, the effect of AA-2G was remarkably inhibited by the addition of castanospermine, an alpha-glucosidase inhibitor; and moreover, repeated additions of AsA to the culture medium during the culture period enhanced the response to the same level as did a single addition of AA-2G [2].
Castanospermine (CSP) inhibits alpha-glucosidase, which is involved in the initial step of N-linked oligosaccharide processing of secretory and membrane glycoproteins [1].
In addition, the enzyme alpha-glucosidase was present only in the methicillin resistant-multiresistant strains, in spite of their origin [3].

References

Alteration of membrane oligosaccharides by castanospermine, an alpha glucosidase inhibitor, enhances immunoglobulin production in Staphylococcus aureus Cowan I-stimulated lymphocyte culture. Karasuno, T., Kanayama, Y., Nishiura, T., Nakao, H., Kurata, Y., Yonezawa, T., Tarui, S. Scand. J. Immunol. (1990) [Pubmed]
Enhancement by ascorbic acid 2-glucoside or repeated additions of ascorbate of mitogen-induced IgM and IgG productions by human peripheral blood lymphocytes. Tanaka, M., Muto, N., Gohda, E., Yamamoto, I. Jpn. J. Pharmacol. (1994) [Pubmed]
Enzymatic characterization of Staphylococcus aureus strains: a possible role of habitat and methicillin-resistance in the determination of the differences observed. Pessione, E., Giunta, C. Microbios (1986) [Pubmed]

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