Gene Review:
spsB - type-I signal peptidase
Staphylococcus aureus RF122
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Disease relevance of spsB
- Molecular cloning and expression of the spsB gene encoding an essential type I signal peptidase from Staphylococcus aureus [1].
- The gene, spsB, encoding a type I signal peptidase has been cloned from the gram-positive eubacterium Staphylococcus aureus [1].
High impact information on spsB
- Experiments whereby the spsB gene was transferred to a plasmid that is temperature sensitive for replication indicate that spsB is an essential gene [1].
- We identified an open reading frame immediately upstream of the spsB gene which encodes a type I signal peptidase homolog of 174 amino acid residues with a calculated molecular mass of 20,146 Da that is predicted to be devoid of catalytic activity [1].
References
- Molecular cloning and expression of the spsB gene encoding an essential type I signal peptidase from Staphylococcus aureus. Cregg, K.M., Wilding, I., Black, M.T. J. Bacteriol. (1996) [Pubmed]
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