High impact information on NaCP60E

• The expression pattern of DSC1 is very different from para during embryonic and larval stages during which there are very few DSC1-expressing cells in either the CNS or PNS [1].
• The strong and widespread expression of DSC1 in the CNS of pupae and adults suggests that the DSC1 channels are likely to provide an important function in neurons during these stages [1].
• Complementation tests between the smi60E mutant and several EP insert lines map the smell-impaired phenotype to the P[lArB] insertion site [2].
• Behavioral assays show that a threefold decrease in DSC1 mRNA is accompanied by a threefold shift in the dose response for avoidance of the repellent odorant, benzaldehyde, toward higher odorant concentrations [2].
• DSC1 channels are expressed in both the central and the peripheral nervous system of adult Drosophila melanogaster [3].

Anatomical context of NaCP60E

• Sh was additionally expressed in the photoreceptor cells of the retina and pupal flight muscle, while para and DSC were not [4].

Other interactions of NaCP60E

• The dsc1 gene encodes an ion channel of unknown function homologous to the paralytic (para) sodium channel, which mediates neuronal excitability [2].
• The most striking result concerns the widespread distribution of DSC1 channels in the PNS, as confirmed by experiments done with the monoclonal antibody 22C10 [3].

Analytical, diagnostic and therapeutic context of NaCP60E

• In situ hybridization reveals widespread expression of the dsc1 gene in the major olfactory organs, the third antennal segment and the maxillary palps, and in the CNS [2].

References