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Gene Review

Sp9  -  trans-acting transcription factor 9

Mus musculus

Synonyms: Transcription factor Sp9
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High impact information on Sp9

  • We show that two closely related buttonhead-like zinc-finger transcription factors, Sp8 and Sp9, are expressed in the AER, and regulate Fgf8 expression and limb outgrowth [1].
  • Embryological and genetic analyses have revealed that Sp8 and Sp9 are ectodermal targets of Fgf10 signaling from the mesenchyme [1].
  • We also found that Wnt/beta-catenin signaling positively regulates Sp8, but not Sp9 [1].


  1. Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos. Kawakami, Y., Esteban, C.R., Matsui, T., Rodríguez-León, J., Kato, S., Belmonte, J.C. Development (2004) [Pubmed]
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