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Gene Review:

KPNA3 - karyopherin alpha 3 (importin alpha 4)

Homo sapiens

Synonyms: IPOA4, Importin alpha Q2, Importin subunit alpha-4, Karyopherin subunit alpha-3, QIP2, ...

Nachury, M.V. et al., Wei, J. et al., Takeda, S. et al., Zhang, H. et al.

Takeda, Fujiwara, Shimizu, Kawai, Shinomiya, Okuno, Ozaki, Katagiri, Shimada, Nagata, Watanabe, Takaichi, Kuga, Suzuki, Hishigaki, Takahashi, Shin, Nakamura, Hirai,

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High impact information on KPNA3

Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor [1].
Interestingly, hSRP1 gamma shows a very selective expression pattern and is most abundantly expressed in skeletal muscle, representing more than 1% of the total protein in this tissue [1].
Recent studies suggest that both the KPNB3 gene and the KPNA3 gene in the long arm of chromosome 13 (13q) are associated with schizophrenia [2].
We detected 7 single nucleotide polymorphisms (SNPs) on 13q14, one (rs6313) present at the HTR2A locus and the other 6 at the KPNA3 locus, among 124 British family trios consisting of mother, father and affected offspring with schizophrenia [3].
From a human fetal-brain cDNA library, we isolated and characterized a novel gene (KPNA3) encoding a protein highly homologous to certain nuclear transport proteins of Xenopus and human [4].

References

Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor. Nachury, M.V., Ryder, U.W., Lamond, A.I., Weis, K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia. Zhang, H., Ju, G., Wei, J., Hu, Y., Liu, L., Xu, Q., Chen, Y., Sun, Z., Liu, S., Yu, Y., Guo, Y., Shen, Y. Neurosci. Lett. (2006) [Pubmed]
The KPNA3 gene may be a susceptibility candidate for schizophrenia. Wei, J., Hemmings, G.P. Neurosci. Res. (2005) [Pubmed]
Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1. Takeda, S., Fujiwara, T., Shimizu, F., Kawai, A., Shinomiya, K., Okuno, S., Ozaki, K., Katagiri, T., Shimada, Y., Nagata, M., Watanabe, T., Takaichi, A., Kuga, Y., Suzuki, M., Hishigaki, H., Takahashi, E., Shin, S., Nakamura, Y., Hirai, Y. Cytogenet. Cell Genet. (1997) [Pubmed]

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KPNA3	Bos taurus
KPNA3	Canis lupus familiaris
kpna3	Danio rerio
KPNA3	Gallus gallus
KPNA3	Macaca mulatta
Kpna3	Mus musculus
KPNA3	Pan troglodytes
Kpna3	Rattus norvegicus
kpna3	Xenopus (Silurana) tropicalis

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