Gene Review:
HTR2A - 5-hydroxytryptamine (serotonin) receptor...
Homo sapiens
Synonyms:
5-HT-2, 5-HT-2A, 5-HT2A, 5-hydroxytryptamine receptor 2A, HTR2, ...
Serretti,
Lorenzi,
Lilli,
Smeraldi,
Oswald,
Souery,
Massat,
Del-Favero,
Linotte,
Papadimitriou,
Dikeos,
Kaneva,
Milanova,
Oruc,
Ivezic,
Serretti,
Lilli,
Van Broeckhoven,
Mendlewicz,
Gorwood,
Adès,
Bellodi,
Cellini,
Collier,
Di Bella,
Di Bernardo,
Estivill,
Fernandez-Aranda,
Gratacos,
Hebebrand,
Hinney,
Hu,
Karwautz,
Kipman,
Mouren-Siméoni,
Nacmias,
Ribasés,
Remschmidt,
Ricca,
Rotella,
Sorbi,
Treasure,
Seifritz,
Moore,
Trachsel,
Bhatti,
Stahl,
Gillin,
Inada,
Yoneda,
Koh,
Sakai,
Himei,
Kinoshita,
Akabame,
Hiraoka,
Sakai,
Zhang,
Kowal,
Nawoschik,
Lou,
Dunlop,
Hill,
Stoltenberg,
Bullard,
Li,
Zucker,
Burmeister,
Sharif,
Kelly,
McLaughlin,
Bronowska,
Chilmonczyk,
Leś,
Edvardsen,
Ostensen,
Sylte,
- Amplicon melting analysis with labeled primers: a closed-tube method for differentiating homozygotes and heterozygotes. Gundry, C.N., Vandersteen, J.G., Reed, G.H., Pryor, R.J., Chen, J., Wittwer, C.T. Clin. Chem. (2003)
- Serotonin-2A and 2C receptor gene polymorphisms in Japanese patients with obstructive sleep apnea. Sakai, K., Takada, T., Nakayama, H., Kubota, Y., Nakamata, M., Satoh, M., Suzuki, E., Akazawa, K., Gejyo, F. Intern. Med. (2005)
- 5-hydroxytryptamine receptors in the human cardiovascular system. Kaumann, A.J., Levy, F.O. Pharmacol. Ther. (2006)
- Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Reavill, C., Kettle, A., Holland, V., Riley, G., Blackburn, T.P. Br. J. Pharmacol. (1999)
- The 5-HT(2A) -1438G/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres. Gorwood, P., Adès, J., Bellodi, L., Cellini, E., Collier, D.A., Di Bella, D., Di Bernardo, M., Estivill, X., Fernandez-Aranda, F., Gratacos, M., Hebebrand, J., Hinney, A., Hu, X., Karwautz, A., Kipman, A., Mouren-Siméoni, M.C., Nacmias, B., Ribasés, M., Remschmidt, H., Ricca, V., Rotella, C.M., Sorbi, S., Treasure, J. Mol. Psychiatry (2002)
- The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Bray, N.J., Buckland, P.R., Hall, H., Owen, M.J., O'Donovan, M.C. Mol. Psychiatry (2004)
- Association Studies of Serotonin System Candidate Genes in Early-onset Obsessive-Compulsive Disorder. Dickel, D.E., Veenstra-Vanderweele, J., Bivens, N.C., Wu, X., Fischer, D.J., Van Etten-Lee, M., Himle, J.A., Leventhal, B.L., Cook, E.H., Hanna, G.L. Biol. Psychiatry (2007)
- Lack of association between the 5HT2A receptor polymorphism (T102C) and unipolar affective disorder in a multicentric European study. Oswald, P., Souery, D., Massat, I., Del-Favero, J., Linotte, S., Papadimitriou, G., Dikeos, D., Kaneva, R., Milanova, V., Oruc, L., Ivezic, S., Serretti, A., Lilli, R., Van Broeckhoven, C., Mendlewicz, J. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2003)
- Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene. Inada, Y., Yoneda, H., Koh, J., Sakai, J., Himei, A., Kinoshita, Y., Akabame, K., Hiraoka, Y., Sakai, T. Psychiatry research. (2003)
- International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylecharane, E.J., Saxena, P.R., Humphrey, P.P. Pharmacol. Rev. (1994)
- Monoaminergic regulation of neuroendocrine function and its modification by cocaine. Levy, A.D., Baumann, M.H., Van de Kar, L.D. Frontiers in neuroendocrinology. (1994)
- 5-HT2A gene promoter polymorphism and anorexia nervosa. Ziegler, A., Görg, T. Lancet (1999)
- 5-HT2A promoter polymorphism -1438G/A, anorexia nervosa, and obsessive-compulsive disorder. Enoch, M.A., Kaye, W.H., Rotondo, A., Greenberg, B.D., Murphy, D.L., Goldman, D. Lancet (1998)
- Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells. Kuemmerle, J.F., Murthy, K.S., Grider, J.R., Martin, D.C., Makhlouf, G.M. Gastroenterology (1995)
- Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. Li, T., Liu, X., Zhao, J., Hu, X., Ball, D.M., Loh, e.l.-.W., Sham, P.C., Collier, D.A. Am. J. Med. Genet. (2002)
- Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders. Serretti, A., Lorenzi, C., Lilli, R., Smeraldi, E. Journal of psychiatric research. (2000)
- Slow wave sleep in humans: role of 5-HT2A and 5-HT2C receptors. Sharpley, A.L., Elliott, J.M., Attenburrow, M.J., Cowen, P.J. Neuropharmacology (1994)
- A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Bryant, H.U., Nelson, D.L., Button, D., Cole, H.W., Baez, M.B., Lucaites, V.L., Wainscott, D.B., Whitesitt, C., Reel, J., Simon, R., Koppel, G.A. Life Sci. (1996)
- Serotonin 2A receptor antagonist treatment reduces dopamine D1 receptor-mediated rotational behavior but not l-DOPA-induced abnormal involuntary movements in the unilateral dopamine-depleted rat. Taylor, J.L., Bishop, C., Ullrich, T., Rice, K.C., Walker, P.D. Neuropharmacology (2006)
- Pharmacogenetics of antidepressant medication intolerance. Murphy, G.M., Kremer, C., Rodrigues, H.E., Schatzberg, A.F. The American journal of psychiatry. (2003)
- Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients. Masellis, M., Basile, V., Meltzer, H.Y., Lieberman, J.A., Sevy, S., Macciardi, F.M., Cola, P., Howard, A., Badri, F., Nöthen, M.M., Kalow, W., Kennedy, J.L. Neuropsychopharmacology (1998)
- Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems. Berg, K.A., Clarke, W.P., Sailstad, C., Saltzman, A., Maayani, S. Mol. Pharmacol. (1994)
- Human trabecular meshwork cells express functional serotonin-2A (5HT2A) receptors: role in IOP reduction. Sharif, N.A., Kelly, C.R., McLaughlin, M. Invest. Ophthalmol. Vis. Sci. (2006)
- 5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression. Verheggen, R., Hundeshagen, A.G., Brown, A.M., Schindler, M., Kaumann, A.J. Br. J. Pharmacol. (1998)
- Distinct functional profiles of aripiprazole and olanzapine at RNA edited human 5-HT2C receptor isoforms. Zhang, J.Y., Kowal, D.M., Nawoschik, S.P., Lou, Z., Dunlop, J. Biochem. Pharmacol. (2006)
- RBI-257: a highly potent dopamine D4 receptor-selective ligand. Kula, N.S., Baldessarini, R.J., Kebabian, J.W., Bakthavachalam, V., Xu, L. Eur. J. Pharmacol. (1997)
- Serotonin and dopamine receptor gene polymorphisms and the risk of extrapyramidal side effects in perphenazine-treated schizophrenic patients. Gunes, A., Scordo, M.G., Jaanson, P., Dahl, M.L. Psychopharmacology (Berl.) (2007)
- Antisocial alcoholism and serotonin-related polymorphisms: association tests. Hill, E.M., Stoltenberg, S.F., Bullard, K.H., Li, S., Zucker, R.A., Burmeister, M. Psychiatr. Genet. (2002)
- The association between the T102C polymorphism of the HTR2A serotonin receptor gene and HDL cholesterol level in Koreans. Choi, J.H., Zhang, S.Y., Park, K.W., Cho, Y.S., Oh, B.H., Lee, M.M., Park, Y.B., Kim, H.S. J. Biochem. Mol. Biol. (2005)
- The serotonin-2A receptor polymorphism and smoking behavior in Japan. Terayama, H., Itoh, M., Fukunishi, I., Iwahashi, K. Psychiatr. Genet. (2004)
- Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Bronowska, A., Chilmonczyk, Z., Leś, A., Edvardsen, O., Ostensen, R., Sylte, I. J. Comput. Aided Mol. Des. (2001)
- Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography. Mintun, M.A., Sheline, Y.I., Moerlein, S.M., Vlassenko, A.G., Huang, Y., Snyder, A.Z. Biol. Psychiatry (2004)
- Effects of chronic administration of interferon alpha A/D on serotonergic receptors in rat brain. Abe, S., Hori, T., Suzuki, T., Baba, A., Shiraishi, H., Yamamoto, T. Neurochem. Res. (1999)
- Selective interaction of ARF1 with the carboxy-terminal tail domain of the 5-HT2A receptor. Robertson, D.N., Johnson, M.S., Moggach, L.O., Holland, P.J., Lutz, E.M., Mitchell, R. Mol. Pharmacol. (2003)
- (N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets. Bourdon, D.M., Mahanty, S.K., Jacobson, K.A., Boyer, J.L., Harden, T.K. J. Thromb. Haemost. (2006)
- The 5-HT1A agonist ipsapirone enhances EEG slow wave activity in human sleep and produces a power spectrum similar to 5-HT2 blockade. Seifritz, E., Moore, P., Trachsel, L., Bhatti, T., Stahl, S.M., Gillin, J.C. Neurosci. Lett. (1996)
- Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors. Kaumann, A.J., Frenken, M., Posival, H., Brown, A.M. Circulation (1994)
- Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism. Tournois, C., Mutel, V., Manivet, P., Launay, J.M., Kellermann, O. J. Biol. Chem. (1998)
- Comparative desensitization of the human 5-HT2A and 5-HT2C receptors expressed in the human neuroblastoma cell line SH-SY5Y. Briddon, S.J., Leslie, R.A., Elliott, J.M. Br. J. Pharmacol. (1998)
- Novel serotonergic mechanisms and clinical experience with nefazodone. Fontaine, R. Clinical neuropharmacology. (1993)
- Serotonin inhibits the induction of NMDA receptor-dependent long-term potentiation in the rat primary visual cortex. Kim, H.S., Jang, H.J., Cho, K.H., Hahn, S.J., Kim, M.J., Yoon, S.H., Jo, Y.H., Kim, M.S., Rhie, D.J. Brain Res. (2006)
- Genetic association analysis of serotonin system genes in bipolar affective disorder. Vincent, J.B., Masellis, M., Lawrence, J., Choi, V., Gurling, H.M., Parikh, S.V., Kennedy, J.L. The American journal of psychiatry. (1999)
- Investigation of serotonin-related genes in antidepressant response. Peters, E.J., Slager, S.L., McGrath, P.J., Knowles, J.A., Hamilton, S.P. Mol. Psychiatry (2004)
- Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. López-Figueroa, A.L., Norton, C.S., López-Figueroa, M.O., Armellini-Dodel, D., Burke, S., Akil, H., López, J.F., Watson, S.J. Biol. Psychiatry (2004)
- Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Abdolmaleky, H.M., Faraone, S.V., Glatt, S.J., Tsuang, M.T. Schizophr. Res. (2004)
- Identification of mRNA for 5-HT1 and 5-HT2 receptor subtypes in human coronary arteries. Ishida, T., Hirata, K., Sakoda, T., Kawashima, S., Akita, H., Yokoyama, M. Cardiovasc. Res. (1999)
- 5-HT2B receptor mRNA in guinea pig superior cervical ganglion. Newberry, N.R., Watkins, C.J., Volenec, A., Flanigan, T.P. Neuroreport (1996)