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Gene Review

AMIGO3  -  adhesion molecule with Ig-like domain 3

Homo sapiens

Synonyms: ALI3, AMIGO-3, Alivin-3, Amphoterin-induced protein 3, KIAA1851, ...
 
 
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Disease relevance of AMIGO3

  • In 10 cases, intercurrent complications (bronchopneumonia, n = 5; bronchopulmonary fistula, n = 2; gastric aspiration, n = 2; thromboembolism, n = 1) triggered the onset of ALI 3 to 12 days after surgery, and this was associated with a 60% mortality rate (secondary ALI) [1].
 

High impact information on AMIGO3

  • We named this gene amphoterin-induced gene and ORF (AMIGO), and also cloned two other novel genes homologous to AMIGO (AMIGO2 and AMIGO3) [2].

References

  1. Risk factors for acute lung injury after thoracic surgery for lung cancer. Licker, M., de Perrot, M., Spiliopoulos, A., Robert, J., Diaper, J., Chevalley, C., Tschopp, J.M. Anesth. Analg. (2003) [Pubmed]
  2. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. Kuja-Panula, J., Kiiltomäki, M., Yamashiro, T., Rouhiainen, A., Rauvala, H. J. Cell Biol. (2003) [Pubmed]
 
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