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Gene Review

AMIGO3  -  adhesion molecule with Ig-like domain 3

Homo sapiens

Synonyms: ALI3, AMIGO-3, Alivin-3, Amphoterin-induced protein 3, KIAA1851, ...
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Disease relevance of AMIGO3

  • In 10 cases, intercurrent complications (bronchopneumonia, n = 5; bronchopulmonary fistula, n = 2; gastric aspiration, n = 2; thromboembolism, n = 1) triggered the onset of ALI 3 to 12 days after surgery, and this was associated with a 60% mortality rate (secondary ALI) [1].

High impact information on AMIGO3

  • We named this gene amphoterin-induced gene and ORF (AMIGO), and also cloned two other novel genes homologous to AMIGO (AMIGO2 and AMIGO3) [2].


  1. Risk factors for acute lung injury after thoracic surgery for lung cancer. Licker, M., de Perrot, M., Spiliopoulos, A., Robert, J., Diaper, J., Chevalley, C., Tschopp, J.M. Anesth. Analg. (2003) [Pubmed]
  2. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. Kuja-Panula, J., Kiiltomäki, M., Yamashiro, T., Rouhiainen, A., Rauvala, H. J. Cell Biol. (2003) [Pubmed]
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