Disease relevance of AMIGO2

• We have discovered DEGA, a novel cDNA differentially expressed in human gastric adenocarcinomas [1].
• METHODS: Twenty-two children (twenty-four hips) with an average age of five years and ten months and varying degrees of congenital hip dysplasia, subluxation, or dislocation were treated with a Dega osteotomy [2].
• A Dega-type osteotomy after closure of the triradiate cartilage in non-walking patients with severe cerebral palsy [3].

High impact information on AMIGO2

• We named this gene amphoterin-induced gene and ORF (AMIGO), and also cloned two other novel genes homologous to AMIGO (AMIGO2 and AMIGO3) [4].
• SETTING: 2 public health department clinics in North Carolina. Participants: 121 adults who had recently emigrated from Vietnam to North Carolina and who were ethnic Vietnamese and ethnic Dega, a minority population group from the central highlands region of Vietnam [5].
• These findings suggest a potential etiologic role for DEGA/AMIGO-2 in gastric adenocarcinoma [1].
• DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity [1].
• Stable expression of a DEGA/AMIGO-2 antisense construct in the gastric adenocarcinoma cell line, AGS, led to altered morphology, increased ploidy, chromosomal instability, decreased cell adhesion/migration, and a nearly complete abrogation of tumorigenicity in nude mice [1].

Biological context of AMIGO2

• Although the cytosolic portion of the DEGA gene product does not contain known protein domains, approximately one-fifth of these residues are either a serine or a threonine, suggesting that DEGA may play a role in signal transduction [1].

Anatomical context of AMIGO2

• The DEGA gene product contains a signal peptide, five leucine-rich repeat motifs and a single IgG, and transmembrane domain, suggesting its residence on the plasma membrane [1].
• The physical findings can be very elusive in the subluxating hip, the radiographic manifestations are different from those encountered in the subluxated hip, and effective treatment requires a pelvic osteotomy that alters the shape of the acetabulum (Pemberton or Dega) [6].
• The study presents the long-term results of operative treatment of spastic subluxation and dislocation of hip joints in cerebral palsy children with open reduction and pelvic transiliac osteotomy by Dega [7].

Associations of AMIGO2 with chemical compounds

• The gas-liquid chromatographic behaviour of the methyl esters was studied on polar [Carbowax 20M, FFAP, DEGA, DEGS, Silar 10C (recently renamed as Apolar 10) and SP 2330], semi-polar (XE-60), and non-polar (SE-30, OV101 and Apiezon L) stationary phases [8].
• This is a report of a study on the cardiac effects of standard-dose halofantrine (24 mg/kg) on a sample of 48 patients selected from a group of 402 Dega (Montagnard) refugees treated for Plasmodium falciparum infection [9].

Other interactions of AMIGO2

• Among them, YAF2 and AMIGO2 were the most plausible candidates to affect growth and psychomotor retardation, respectively, in both cases [10].

Analytical, diagnostic and therapeutic context of AMIGO2

• Dega osteotomy for the treatment of congenital dysplasia of the hip [2].

References