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Gene Review

AMIGO2  -  adhesion molecule with Ig-like domain 2

Homo sapiens

Synonyms: ALI1, AMIGO-2, Alivin-1, Amphoterin-induced protein 2, DEGA, ...
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Disease relevance of AMIGO2

  • We have discovered DEGA, a novel cDNA differentially expressed in human gastric adenocarcinomas [1].
  • METHODS: Twenty-two children (twenty-four hips) with an average age of five years and ten months and varying degrees of congenital hip dysplasia, subluxation, or dislocation were treated with a Dega osteotomy [2].
  • A Dega-type osteotomy after closure of the triradiate cartilage in non-walking patients with severe cerebral palsy [3].

High impact information on AMIGO2


Biological context of AMIGO2


Anatomical context of AMIGO2

  • The DEGA gene product contains a signal peptide, five leucine-rich repeat motifs and a single IgG, and transmembrane domain, suggesting its residence on the plasma membrane [1].
  • The physical findings can be very elusive in the subluxating hip, the radiographic manifestations are different from those encountered in the subluxated hip, and effective treatment requires a pelvic osteotomy that alters the shape of the acetabulum (Pemberton or Dega) [6].
  • The study presents the long-term results of operative treatment of spastic subluxation and dislocation of hip joints in cerebral palsy children with open reduction and pelvic transiliac osteotomy by Dega [7].

Associations of AMIGO2 with chemical compounds

  • The gas-liquid chromatographic behaviour of the methyl esters was studied on polar [Carbowax 20M, FFAP, DEGA, DEGS, Silar 10C (recently renamed as Apolar 10) and SP 2330], semi-polar (XE-60), and non-polar (SE-30, OV101 and Apiezon L) stationary phases [8].
  • This is a report of a study on the cardiac effects of standard-dose halofantrine (24 mg/kg) on a sample of 48 patients selected from a group of 402 Dega (Montagnard) refugees treated for Plasmodium falciparum infection [9].

Other interactions of AMIGO2

  • Among them, YAF2 and AMIGO2 were the most plausible candidates to affect growth and psychomotor retardation, respectively, in both cases [10].

Analytical, diagnostic and therapeutic context of AMIGO2

  • Dega osteotomy for the treatment of congenital dysplasia of the hip [2].


  1. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. Rabenau, K.E., O'Toole, J.M., Bassi, R., Kotanides, H., Witte, L., Ludwig, D.L., Pereira, D.S. Oncogene (2004) [Pubmed]
  2. Dega osteotomy for the treatment of congenital dysplasia of the hip. Grudziak, J.S., Ward, W.T. The Journal of bone and joint surgery. American volume. (2001) [Pubmed]
  3. A Dega-type osteotomy after closure of the triradiate cartilage in non-walking patients with severe cerebral palsy. Robb, J.E., Brunner, R. The Journal of bone and joint surgery. British volume. (2006) [Pubmed]
  4. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. Kuja-Panula, J., Kiiltomäki, M., Yamashiro, T., Rouhiainen, A., Rauvala, H. J. Cell Biol. (2003) [Pubmed]
  5. Delayed tuberculin reactivity in persons of Indochinese origin: implications for preventive therapy. Robertson, J.M., Burtt, D.S., Edmonds, K.L., Molina, P.L., Kiefe, C.I., Ellner, J.J. Ann. Intern. Med. (1996) [Pubmed]
  6. The subluxating or wandering femoral head in developmental dislocation of the hip. Coleman, S.S. Journal of pediatric orthopedics. (1995) [Pubmed]
  7. Dega's transiliac osteotomy in the treatment of spastic hip subluxation and dislocation in cerebral palsy. Jóźwiak, M., Marciniak, W., Piontek, T., Pietrzak, S. Journal of pediatric orthopaedics. Part B / European Paediatric Orthopaedic Society, Pediatric Orthopaedic Society of North America. (2000) [Pubmed]
  8. Fatty acids. VII. Gas-liquid chromatographic properties of all dimethylene interrupted methyl trans,trans-octadecadienoates. Lam, C.H., Lie Ken Jie, M.S. J. Chromatogr. (1976) [Pubmed]
  9. Cardiac effects of standard-dose halofantrine therapy. Matson, P.A., Luby, S.P., Redd, S.C., Rolka, H.R., Meriwether, R.A. Am. J. Trop. Med. Hyg. (1996) [Pubmed]
  10. Phenotype-genotype correlation in two patients with 12q proximal deletion. Miyake, N., Tonoki, H., Gallego, M., Harada, N., Shimokawa, O., Yoshiura, K., Ohta, T., Kishino, T., Niikawa, N., Matsumoto, N. J. Hum. Genet. (2004) [Pubmed]
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