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Gene Review:

lark - CG8597 gene product from transcript CG8597-RD

Drosophila melanogaster

Synonyms: CG8597, Dmel\CG8597, LARK, Lark, RNA-binding protein lark, ...

McNeil, G.P. et al., Markus, M.A. et al.

McNeil, Smith, Galioto,

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Disease relevance of lark

Elimination of maternal expression of the Drosophila RNA-binding protein Lark results in female sterility [1].

High impact information on lark

The Drosophila RNA-binding protein Lark is required for the organization of the actin cytoskeleton and Hu-li tai shao localization during oogenesis [1].
These mutant phenotypes are likely due to disruption of an RNA-binding function of Lark as similar phenotypes were observed in flies carrying specific RNA-binding domain mutations [1].
We propose that Lark functions during oogenesis as an RNA-binding protein, regulating mRNAs required for nurse cell transport or apoptosis [1].
Lark is an RNA-binding protein of the RNA recognition motif (RRM) class and, in Drosophila, Lark is required for embryonic development [2].

References

The Drosophila RNA-binding protein Lark is required for the organization of the actin cytoskeleton and Hu-li tai shao localization during oogenesis. McNeil, G.P., Smith, F., Galioto, R. Genesis (2004) [Pubmed]
Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties. Markus, M.A., Morris, B.J. DNA Cell Biol. (2006) [Pubmed]

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