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Gene Review:

Ilp2 - Insulin-like peptide 2

Drosophila melanogaster

Synonyms: CG8167, DILP, DILP-2, DILP2, Dilp, ...

Wu, Q. et al., Ikeya, T. et al., de Velasco, B. et al.

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High impact information on Ilp2

Moreover, up-regulation of Drosophila p70/S6 kinase activity in DILP neurons led to attenuated hunger response by fasted larvae, whereas its down-regulation triggered fed larvae to display motivated foraging and feeding [1].
We show that in addition to the Drosophila insulin-like peptide 2 (dilp2) gene, overexpression of dilp1 and dilp3-7 is sufficient to promote growth [2].
NSCs labeled by the expression of Drosophila insulin-like peptide (Dilp), FMRF, and myomodulin form part of the Dchx1 expressing PI domain [3].

References

Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. Wu, Q., Zhang, Y., Xu, J., Shen, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Ikeya, T., Galic, M., Belawat, P., Nairz, K., Hafen, E. Curr. Biol. (2002) [Pubmed]
Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain. de Velasco, B., Erclik, T., Shy, D., Sclafani, J., Lipshitz, H., McInnes, R., Hartenstein, V. Dev. Biol. (2007) [Pubmed]

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