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Gene Review:

maml1 - mastermind-like 1

Xenopus laevis

Synonyms: mam-1, mam1, xmam1

Katada, T. et al., Katada, T. et al.

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High impact information on XMam1

The nrp-1-positive cell mass was produced by XMam1 without expression of the Notch target gene, XESR-1, and not by the activation form of Notch, NICD [1].
Whole-mount in situ hybridization showed that XMam1 mRNA was present in the ectoderm by the gastrula stage and localized at the anterior neural region in the neurula stage [2].
Overall, Mastermind proteins consist of a basic domain, two acidic domains and a glutamine-rich domain, which are highly conserved among species [2].

Biological context of XMam1

XMam1, Xenopus Mastermind1, induces neural gene expression in a Notch-independent manner [1].
Previously we showed that XMam1, Xenopus Mastermind1, was essential in the transactivation of a Notch target gene, XESR-1, and was involved in primary neurogenesis [1].

References

XMam1, Xenopus Mastermind1, induces neural gene expression in a Notch-independent manner. Katada, T., Ito, M., Kojima, Y., Miyatani, S., Kinoshita, T. Mech. Dev. (2006) [Pubmed]
XMam1, the Xenopus homologue of mastermind, is essential to primary neurogenesis in Xenopus laevis embryos. Katada, T., Kinoshita, T. Int. J. Dev. Biol. (2003) [Pubmed]

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