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Gene Review

maml1  -  mastermind-like 1

Xenopus laevis

Synonyms: mam-1, mam1, xmam1
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High impact information on XMam1

  • The nrp-1-positive cell mass was produced by XMam1 without expression of the Notch target gene, XESR-1, and not by the activation form of Notch, NICD [1].
  • Whole-mount in situ hybridization showed that XMam1 mRNA was present in the ectoderm by the gastrula stage and localized at the anterior neural region in the neurula stage [2].
  • Overall, Mastermind proteins consist of a basic domain, two acidic domains and a glutamine-rich domain, which are highly conserved among species [2].

Biological context of XMam1


  1. XMam1, Xenopus Mastermind1, induces neural gene expression in a Notch-independent manner. Katada, T., Ito, M., Kojima, Y., Miyatani, S., Kinoshita, T. Mech. Dev. (2006) [Pubmed]
  2. XMam1, the Xenopus homologue of mastermind, is essential to primary neurogenesis in Xenopus laevis embryos. Katada, T., Kinoshita, T. Int. J. Dev. Biol. (2003) [Pubmed]
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